Transgenerational epigenetic imprints on mate preference.

Transgenerational epigenetic imprints on mate preference. Research Abstract Details 

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Transgenerational epigenetic imprints on mate preference. Abstract Text:

David Crews,Andrea C Gore,Timothy S Hsu,Nygerma L Dangleben,Michael Spinetta,Timothy Schallert,Matthew D Anway,Michael K Skinner,

Environmental contamination by endocrine-disrupting chemicals (EDC) can have epigenetic effects (by DNA methylation) on the germ line and promote disease across subsequent generations. In natural populations, both sexes may encounter affected as well as unaffected individuals during the breeding season, and any diminution in attractiveness could compromise reproductive success. Here we examine mate preference in male and female rats whose progenitors had been treated with the antiandrogenic fungicide vinclozolin. This effect is sex-specific, and we demonstrate that females three generations removed from the exposure discriminate and prefer males who do not have a history of exposure, whereas similarly epigenetically imprinted males do not exhibit such a preference. The observations suggest that the consequences of EDCs are not just transgenerational but can be "transpopulational", because in many mammalian species, males are the dispersing sex. This result indicates that epigenetic transgenerational inheritance of EDC action represents an unappreciated force in sexual selection. Our observations provide direct experimental evidence for a role of epigenetics as a determinant factor in evolution.

Transgenerational epigenetic imprints on mate preference. Publishing Authors By Initials

D Crews,AC Gore,TS Hsu,NL Dangleben,M Spinetta,T Schallert,MD Anway,MK Skinner,

For similar animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats: rats, sprague-dawley research abstracts see: animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats: rats, sprague-dawley research

PUBMED ID PMID:

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Transgenerational epigenetic imprints on mate preference. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 104

Page Numbers: 5942-6

Journal Abbreviation:

ISSN: 0027-8424

DAY: 26

MONTH: 03

YEAR: 2007

Transgenerational epigenetic imprints on mate preference. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7505876

Transgenerational epigenetic imprints on mate preference. Keywords Mesh Terms:

KEYWORDS: Rats, Sprague-Dawley

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Transgenerational epigenetic imprints on mate preference. Information

Substance Name: vinclozolin

Registry Number: 50471-44-8

Grant and Affiliation Information for Transgenerational epigenetic imprints on mate preference.

AFFILIATION: Section of Integrative Biology,University of Texas, Austin, TX 78712, USA.

Country: United States

AGENCY: United States NIMH

GRANT: MH 068273

ACRONYM: MH

MEDLINETA: Proc Natl Acad Sci U S A

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