[Transforming growth factor beta(1) and bone morphogenetic protein 2 induce the differentiation of odontoblasts in vitro]

[Transforming growth factor beta(1) and bone morphogenetic protein 2 induce the differentiation of odontoblasts in vitro] Research Abstract Details 

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[Transforming growth factor beta(1) and bone morphogenetic protein 2 induce the differentiation of odontoblasts in vitro] Abstract Text:

Mingwen Fan,Qi Zhu,Zhuan Bian,Qi Zhang,

OBJECTIVE: To investigate the effects of transforming growth factor beta(1) (TGF-beta(1)) and bone morphogenetic protein 2 (BMP2) combined with heparin on odontoblast differentiation. METHODS: Trypsin-isolated dental papillae from day 17 mandibular first molar were cultured in semisolid-agar medium for 6d. Recombinant human TGF-beta(1) and BMP2 combined with heparin were added to the medium. RESULTS: TGF-beta(1) and BMP2 combined with heparin induced differentiation of odontoblasts and promoted matrix secretion. Odontoblast differentiation never occurred when TGF-beta(1) or BMP2 were added alone to the medium, whereas an increase in extracellular matrix production was observed. CONCLUSION: These results demonstrate that both TGF-beta(1) and BMP2 stimulate the cytological and functional differentiation of preodontoblasts, and that heparin might play important role as a substrate.

[Transforming growth factor beta(1) and bone morphogenetic protein 2 induce the differentiation of odontoblasts in vitro] Publishing Authors By Initials

M Fan,Q Zhu,Z Bian,Q Zhang,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta: transforming growth factor beta1 research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta: transforming growth factor beta1 research

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[Transforming growth factor beta(1) and bone morphogenetic protein 2 induce the differentiation of odontoblasts in vitro] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua kou qiang yi xue za zhi = Zhonghua kouqia

VOLUME: 37

Page Numbers: 106-8

Journal Abbreviation: Zhonghua Kou Qiang Yi Xue Za Z

ISSN: 1002-0098

DAY: 19

MONTH: Mar

YEAR: 2002

[Transforming growth factor beta(1) and bone morphogenetic protein 2 induce the differentiation of odontoblasts in vitro] Information

Number of References:

LANGUAGE: chi

NlmUniqueID: 8711066

[Transforming growth factor beta(1) and bone morphogenetic protein 2 induce the differentiation of odontoblasts in vitro] Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta1

MESH TERMS: pharmacology

Chemical & Substance for Abstract: [Transforming growth factor beta(1) and bone morphogenetic protein 2 induce the differentiation of odontoblasts in vitro] Information

Substance Name: Heparin

Registry Number: 9005-49-6

Grant and Affiliation Information for [Transforming growth factor beta(1) and bone morphogenetic protein 2 induce the differentiation of odontoblasts in vitro]

AFFILIATION: Department of Operative Dentistry and Endodontics, School of Stomatology, Wuhan University, Wuhan 430079, China.

Country: China

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MEDLINETA: Zhonghua Kou Qiang Yi Xue Za Z

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