Transforming growth factor beta (TGF-beta) and autoimmunity.

Transforming growth factor beta (TGF-beta) and autoimmunity. Research Abstract Details 

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Transforming growth factor beta (TGF-beta) and autoimmunity. Abstract Text:

Christopher A Aoki,Andrea T Borchers,Ming Li,Richard A Flavell,Christopher L Bowlus,Aftab A Ansari,M Eric Gershwin,

TGF-beta1 deficient mice develop multifocal inflammatory autoimmune disease and serve as a valuable animal model of autoimmunity. Transgenic expression of a dominant negative form of TGF-beta receptor type II in T cells have enabled the study of cell lineage specific effects of TGF-beta providing clues to the potential etiology of autoimmunity. These studies suggest that TGF-beta deficiency may induce autoimmune disease by influencing a number of immunological phenomena including lymphocyte activation and differentiation, cell adhesion molecule expression, regulatory T cell function, the expression of MHC molecules and cytokines, and cell apoptosis. The spectrum of effects appears to be significant in mucosal immunity and may contribute to the pathogenesis of inflammatory bowel disease.

Transforming growth factor beta (TGF-beta) and autoimmunity. Publishing Authors By Initials

CA Aoki,AT Borchers,M Li,RA Flavell,CL Bowlus,AA Ansari,ME Gershwin,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research

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Transforming growth factor beta (TGF-beta) and autoimmunity. Journal Published:

PUBLICATION TYPE: Review

Journal: Autoimmunity reviews

VOLUME: 4

Page Numbers: 450-9

Journal Abbreviation:

ISSN: 1568-9972

DAY: 27

MONTH: Sep

YEAR: 2005

Transforming growth factor beta (TGF-beta) and autoimmunity. Information

Number of References: 40

LANGUAGE: eng

NlmUniqueID: 101128967

Transforming growth factor beta (TGF-beta) and autoimmunity. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta

MESH TERMS: physiology

Chemical & Substance for Abstract: Transforming growth factor beta (TGF-beta) and autoimmunity. Information

Substance Name: Transforming Growth Factor beta

Registry Number: 0

Grant and Affiliation Information for Transforming growth factor beta (TGF-beta) and autoimmunity.

AFFILIATION: Division of Gastroenterology, Department of Internal Medicine, University of California Davis, Davis, CA 95616, United States.

Country: Netherlands

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MEDLINETA: Autoimmun Rev

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