Transforming growth factor-beta superfamily members expressed in rat incisor pulp.

Transforming growth factor-beta superfamily members expressed in rat incisor pulp. Research Abstract Details 

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Transforming growth factor-beta superfamily members expressed in rat incisor pulp. Abstract Text:

M Nakashima,T Toyono,T Murakami,A Akamine,M Nakashima,T Toyono,T Murakami,A Akamine,

The transforming growth factor (TGF)-beta superfamily comprises more than 35 structurally related genes that have been implicated in embryonic induction and morphogenesis. Different superfamily members may have distinct regulatory roles in tooth development and maintenance. Degenerate primer sets derived from the highly conserved carboxy terminal region of the TGF-beta superfamily were used for reverse transcriptase polymerase with poly(A)+ RNA from the rat incisor pulp as a template. TGF-beta superfamily members expressed in the pulp with known potential to differentiate into odontoblasts and to form dentine were identified. Nucleotide-sequence analysis of the amplified cDNAs identified those encoding activin-betaB; bone morphogenic protein (BMP)-2, -4, -7 and -8; growth/differentiation factor (GDF)-1, -5 and -6; and glial cell line-derived neurotrophic factor. In addition, Northern blot analysis detected TGF-beta1 -beta2 and -beta3; activin-betaA; BMP-6 and GDF-7 mRNA transcripts in the pulp. Coordinated expression of TGF-beta superfamily members in pulp may be critical in tooth development and repair.

Transforming growth factor-beta superfamily members expressed in rat incisor pulp. Publishing Authors By Initials

M Nakashima,T Toyono,T Murakami,A Akamine,M Nakashima,T Toyono,T Murakami,A Akamine,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research

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Transforming growth factor-beta superfamily members expressed in rat incisor pulp. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Archives of oral biology

VOLUME: 43

Page Numbers: 745-51

Journal Abbreviation: Arch. Oral Biol.

ISSN: 0003-9969

DAY: 19

MONTH: Sep

YEAR: 1998

Transforming growth factor-beta superfamily members expressed in rat incisor pulp. Information

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LANGUAGE: eng

NlmUniqueID: 116711

Transforming growth factor-beta superfamily members expressed in rat incisor pulp. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta

MESH TERMS: genetics

Chemical & Substance for Abstract: Transforming growth factor-beta superfamily members expressed in rat incisor pulp. Information

Substance Name: myelopeptides

Registry Number: 137833-32-0

Grant and Affiliation Information for Transforming growth factor-beta superfamily members expressed in rat incisor pulp.

AFFILIATION: Department of Operative Dentistry and Endodontology, Faculty of Dentistry, Kyushu University, Fukuoka, Japan.

Country: ENGLAND

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MEDLINETA: Arch Oral Biol

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