Transferrin reverses the anti-invasive activity of human prostate cancer cells that overexpress sema3E.

Transferrin reverses the anti-invasive activity of human prostate cancer cells that overexpress sema3E. Research Abstract Details 

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Transferrin reverses the anti-invasive activity of human prostate cancer cells that overexpress sema3E. Abstract Text:

Jeffery G Herman,Gary G Meadows,Jeffery G Herman,Gary G Meadows,

In vitro invasion and adhesion of stably semaphorin (sema) 3E-transfected PC-3 prostate cancer cells were determined in the presence and absence of transferrin. Invasion and adhesion decreased compared to untransfected cells; however, transferrin reversed the effects. Transferrin differentially regulated E-cadherin and beta-catenin in these cells. Insulin growth factor 3 (IGFBP3) negated the invasive and adhesive effects of transferrin. Transferrin increased binding of insulin growth factor (IGF)-1 to the activated IGF-1 receptor, and IGF-1 mimicked the invasive and adhesive effects of transferrin. These data suggest that transferrin modulates sema3E-transfected cells through an IGFBP3/IGF-1-dependent pathway, in part, by regulation of adhesion proteins.

Transferrin reverses the anti-invasive activity of human prostate cancer cells that overexpress sema3E. Publishing Authors By Initials

JG Herman,GG Meadows,JG Herman,GG Meadows,

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Transferrin reverses the anti-invasive activity of human prostate cancer cells that overexpress sema3E. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: International journal of oncology

VOLUME: 31

Page Numbers: 1267-72

Journal Abbreviation: Int. J. Oncol.

ISSN: 1019-6439

DAY: 3

MONTH: Nov

YEAR: 2007

Transferrin reverses the anti-invasive activity of human prostate cancer cells that overexpress sema3E. Information

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LANGUAGE: eng

NlmUniqueID: 9306042

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Grant and Affiliation Information for Transferrin reverses the anti-invasive activity of human prostate cancer cells that overexpress sema3E.

AFFILIATION: The Pharmacology and Toxicology Graduate Program and the Cancer Prevention and Research Center, College of Pharmacy, Washington State University, Pullman, WA 99164-6713, USA.

Country: Greece

AGENCY: United States NCI

GRANT: CA 101035

ACRONYM: CA

MEDLINETA: Int J Oncol

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