Transfer of suppressor of cytokine signaling 3 by an oncolytic adenovirus induces potential antitumor activities in hepatocellular carcinoma.

Transfer of suppressor of cytokine signaling 3 by an oncolytic adenovirus induces potential antitumor activities in hepatocellular carcinoma. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Transfer of suppressor of cytokine signaling 3 by an oncolytic adenovirus induces potential antitumor activities in hepatocellular carcinoma. Abstract Text:

Qiang Cui,Wei Jiang,Yingxin Wang,Chen Lv,Jingjing Luo,Wei Zhang,Fang Lin,Yuexiang Yin,Rong Cai,Ping Wei,Cheng Qian,Qiang Cui,Wei Jiang,Yingxin Wang,Chen Lv,Jingjing Luo,Wei Zhang,Fang Lin,Yuexiang Yin,Rong Cai,Ping Wei,Cheng Qian,

The constitutive activation of signal transducer and activator of transcription 3 (STAT3) participates in carcinogenesis through up-regulation of genes encoding apoptosis inhibitors and cell cycle regulators, such as Bcl-xL, cyclins D1 and D2, and c-myc. Suppressor of cytokine signaling 3 (SOCS3) is one of the negative regulators of cytokine signaling and is frequently silenced in diverse cancers. In this study, we explored whether restoration of SOCS3 by oncolytic adenoviral vectors could inhibit the constitutive activation of the Janus kinase/STAT pathway and suppress tumor growth. Our data showed that SOCS3 was down-expressed in all liver tumor cell lines. The incorporation of SOCS3 or SOCS3 fused with cell-penetrating peptides (cpp-SOCS3) did not alter adenoviral replication selectively in liver tumor cells. The infection of cells with adenovirus CN305 (AdCN305)-SOCS3 and AdCN305-cpp-SOCS3 resulted in dramatic cytotoxicity in liver tumor cells. However, no cytotoxic effect was observed in normal cells infected with these vectors. Infection of liver tumor cells with AdCN305-SOCS3 and AdCN305-cpp-SOCS3 resulted in nearly complete inhibition of STAT3 phosphorylation and down-regulation of cyclin D1 and Bcl-xL. Treatment of the established tumor by AdCN305-SOCS3 and AdCN305-cpp-SOCS3 caused significant suppression of tumor growth. The suppression of tumor growth was due to the inhibition of STAT3 phosphorylation and induction of tumor cell death. Conclusion: This study suggests that transfer of SOCS3 by an oncolytic adenovirus represents a potent approach for cancer therapy. (HEPATOLOGY 2007.).

Transfer of suppressor of cytokine signaling 3 by an oncolytic adenovirus induces potential antitumor activities in hepatocellular carcinoma. Publishing Authors By Initials

Q Cui,W Jiang,Y Wang,C Lv,J Luo,W Zhang,F Lin,Y Yin,R Cai,P Wei,C Qian,Q Cui,W Jiang,Y Wang,C Lv,J Luo,W Zhang,F Lin,Y Yin,R Cai,P Wei,C Qian,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Transfer of suppressor of cytokine signaling 3 by an oncolytic adenovirus induces potential antitumor activities in hepatocellular carcinoma. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Hepatology (Baltimore, Md.)

VOLUME: 47

Page Numbers: 105-12

Journal Abbreviation: Hepatology

ISSN: 1527-3350

DAY: 2

MONTH: Jan

YEAR: 2008

Transfer of suppressor of cytokine signaling 3 by an oncolytic adenovirus induces potential antitumor activities in hepatocellular carcinoma. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8302946

Transfer of suppressor of cytokine signaling 3 by an oncolytic adenovirus induces potential antitumor activities in hepatocellular carcinoma. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Transfer of suppressor of cytokine signaling 3 by an oncolytic adenovirus induces potential antitumor activities in hepatocellular carcinoma. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Transfer of suppressor of cytokine signaling 3 by an oncolytic adenovirus induces potential antitumor activities in hepatocellular carcinoma.

AFFILIATION: Xinyuan Institute of Medicine and Biotechnology, School of Life Sciences, Zhejiang Sci-Tech University, Hangzhou, China.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Hepatology

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Transfer of suppressor of cytokine signaling 3 by an oncolytic adenovirus induces potential antitumor activities in hepatocellular carcinoma Related Publications

• Constructing molecular classifiers for the accurate prognosis of lung adenocarcinoma.
• Imaging Glucose-Regulated Insulin Secretion and Gene Expression in Single Islet beta-Cells: Control by AMP-Activated Protein Kinase.
• [A misdiagnosed case of imported falciparum malaria]
• [Aminopeptidase inhibitor Bestatin induces HL-60 cell apoptosis through activating caspase 3]
• [Analysis on causes of death of childhood leukemia from 1981 to 2000 in the city of Tianjin]
• [Application of flow cytometry to detect PP65 antigenemia for diagnosis and monitoring of human cytomegalovirus infection]
• [Application of glycosyl fluorides in the study on glycosidases]
• [Biomechanical experiment of non-stemmed anatomical total hip prosthesis arthroplasty in vitro]
• [Clinical study on acute lung injury and adult respiratory distress synolrome]
• [Detection of WT1 expression in bone marrow of acute leukemia patients with real-time quantitative RT-PCR.]
• [Determination of methanol and ethanol in serum by gas chromatography.]
• [Determination of trace selenium in spirulina by continuous-flow hydride generation atomic absorption spectrometry]
• [Dynamic monitering of Ph positive cells during early post-transplant period in chronic granulocytic leukemia by interphase FISH]
• [Effect of selective cyclooxygenase-2 inhibitor celebrex on expression of vascular endothelial growth factor (VEGF) in pancreatic carcinoma]
• [Effect of sodium iron chlorophyllin (SIC) on CFU-E and CFU-GM yields of normal and anemic animal models]
• [Effects of different doses of hydrocortisone on acute lung injury in rats with early septic shock induced by Escherichia coli]
• [Effects of external counterpulsation on the pulsatility of blood pressure and blood flow in dogs]
• [Effects of hydrocortisone on circulating and intramyocardial inflammatory mediators in severe septic rats with myocardial injury induced by Escherichia coli]
• [Hepatic failure after porta-systemic venous shunt in hepato-cirrhosis]
• [In Process Citation]
• [Iron, transferrin and transferrin receptor in the brain]
• [Micro-Raman and fluorescence spectra of several agrochemicals]
• [Multivariate analysis of prognostic factors in Philadelphia chromosome-positive chronic granulocytic leukemia]
• [Observation of long-term therapeutic outcome in chronic granulocytic leukemia]
• [Parainfluenza virus infections in pediatric patients with acute respiratory infections in Beijing during 2001 - 2003]
• [Rapid determination of trace Sb in plastic pipes for dringing water by GFAAS]
• [The evolutionary traits of mitocondrial ND4-ND4L in Drosophila melanogaster species group]
• [Three-dimensional finite element analysis of the biomechanical effects of multiloop edgewise archwire (MEAW)]
• [Value of blinded sampling methods in the pathogenic diagnosis of ventilator-associated pneumonia]
• [Vascular endothelial growth factor expression in focal cerebral ischemia/reperfusion in injury in rats]