Transfer of methadone across the dually perfused preterm human placental lobule.

Transfer of methadone across the dually perfused preterm human placental lobule. Research Abstract Details 

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Transfer of methadone across the dually perfused preterm human placental lobule. Abstract Text:

Tatiana N Nanovskaya,Ilona A Nekhayeva,Gary D V Hankins,Mahmoud S Ahmed,Tatiana N Nanovskaya,Ilona A Nekhayeva,Gary D V Hankins,Mahmoud S Ahmed,

OBJECTIVE: The objective of the study was to determine the effect of gestational age and P-glycoprotein expression on transplacental transfer of methadone. STUDY DESIGN: Dual perfusion of placental lobule was utilized. Methadone (200 ng/mL) and its [3H]-isotope were cotransfused from the maternal-to-fetal circuit with the marker compound antipyrine (20 microg/mL) and its [14C]-isotope. Concentration of the drugs in trophoblast tissue and both circuits was determined by liquid scintillation spectrometry. RESULTS: Fetal transfer rate of methadone in preterm placentas was 19 +/- 5.8%, and in term placentas it was 31 +/- 9.7% (P < .01). Clearance index of methadone in preterm placentas (0.57 +/- 0.2) was lower than in term placentas (0.95 +/- 0.3, P < .01). P-glycoprotein expression was higher in preterm than term placentas. CONCLUSION: The ex vivo transfer of methadone across preterm placentas is 30% lower than in term placentas.

Transfer of methadone across the dually perfused preterm human placental lobule. Publishing Authors By Initials

TN Nanovskaya,IA Nekhayeva,GD Hankins,MS Ahmed,TN Nanovskaya,IA Nekhayeva,GD Hankins,MS Ahmed,

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Transfer of methadone across the dually perfused preterm human placental lobule. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: American journal of obstetrics and gynecology

VOLUME: 198

Page Numbers: 126.e1-4

Journal Abbreviation: Am. J. Obstet. Gynecol.

ISSN: 1097-6868

DAY: 1

MONTH: Jan

YEAR: 2008

Transfer of methadone across the dually perfused preterm human placental lobule. Information

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LANGUAGE: eng

NlmUniqueID: 370476

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Grant and Affiliation Information for Transfer of methadone across the dually perfused preterm human placental lobule.

AFFILIATION: Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX 77555-0587, USA.

Country: United States

AGENCY: United States NIDA

GRANT: DA13431

ACRONYM: DA

MEDLINETA: Am J Obstet Gynecol

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