Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid.

Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid. Research Abstract Details 

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Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid. Abstract Text:

Catherine ,Feng Wang,Masayoshi Arai,Manzour Hernando ,Roberto Colangeli,Laurent Kremer,Torin R Weisbrod,David Alland,James C Sacchettini,William R Jacobs,

Isoniazid is one of the most effective antituberculosis drugs, yet its precise mechanism of action is still controversial. Using specialized linkage transduction, a single point mutation allele (S94A) within the putative target gene inhA was transferred in Mycobacterium tuberculosis. The inhA(S94A) allele was sufficient to confer clinically relevant levels of resistance to isoniazid killing and inhibition of mycolic acid biosynthesis. This resistance correlated with the decreased binding of the INH-NAD inhibitor to InhA, as shown by enzymatic and X-ray crystallographic analyses, and establishes InhA as the primary target of isoniazid action in M. tuberculosis.

Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid. Publishing Authors By Initials

C ,F Wang,M Arai,MH ,R Colangeli,L Kremer,TR Weisbrod,D Alland,JC Sacchettini,WR Jacobs,

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Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Nature medicine

VOLUME: 12

Page Numbers: 1027-9

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ISSN: 1078-8956

DAY: 13

MONTH: 08

YEAR: 2006

Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid.

AFFILIATION: Howard Hughes Medical Institute, Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA.

Country: United States

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MEDLINETA: Nat Med

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