Transcriptional regulation of the Drosophila melanogaster muscle myosin heavy-chain gene.

Transcriptional regulation of the Drosophila melanogaster muscle myosin heavy-chain gene. Research Abstract Details 

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Transcriptional regulation of the Drosophila melanogaster muscle myosin heavy-chain gene. Abstract Text:

Norbert K Hess,Phillip A Singer,Kien Trinh,Massoud Nikkhoy,Sanford I Bernstein,Norbert K Hess,Phillip A Singer,Kien Trinh,Massoud Nikkhoy,Sanford I Bernstein,

We show that a 2.6kb fragment of the muscle myosin heavy-chain gene (Mhc) of Drosophila melanogaster (containing 458 base pairs of upstream sequence, the first exon, the first intron and the beginning of the second exon) drives expression in all muscles. Comparison of the minimal promoter to Mhc genes of 10 Drosophila species identified putative regulatory elements in the upstream region and in the first intron. The first intron is required for expression in four small cells of the tergal depressor of the trochanter (jump) muscle and in the indirect flight muscle. The 3'-end of this intron is important for Mhc transcription in embryonic body wall muscle and contains AT-rich elements that are protected from DNase I digestion by nuclear proteins of Drosophila embryos. Sequences responsible for expression in embryonic, adult body wall and adult head muscles are present both within and outside the intron. Elements important for expression in leg muscles and in the large cells of the jump muscle flank the intron. We conclude that multiple transcriptional regulatory elements are responsible for Mhc expression in specific sets of Drosophila muscles.

Transcriptional regulation of the Drosophila melanogaster muscle myosin heavy-chain gene. Publishing Authors By Initials

NK Hess,PA Singer,K Trinh,M Nikkhoy,SI Bernstein,NK Hess,PA Singer,K Trinh,M Nikkhoy,SI Bernstein,

For similar investigative techniques: genetic techniques: sequence analysis: sequence analysis, dna research abstracts see: investigative techniques: genetic techniques: sequence analysis: sequence analysis, dna research

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Transcriptional regulation of the Drosophila melanogaster muscle myosin heavy-chain gene. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Gene expression patterns : GEP

VOLUME: 7

Page Numbers: 413-22

Journal Abbreviation: Gene Expr. Patterns

ISSN: 1567-133X

DAY: 26

MONTH: 11

YEAR: 2006

Transcriptional regulation of the Drosophila melanogaster muscle myosin heavy-chain gene. Information

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LANGUAGE: eng

NlmUniqueID: 101167473

Transcriptional regulation of the Drosophila melanogaster muscle myosin heavy-chain gene. Keywords Mesh Terms:

KEYWORDS: Sequence Analysis, DNA

MESH TERMS: metabolism

Chemical & Substance for Abstract: Transcriptional regulation of the Drosophila melanogaster muscle myosin heavy-chain gene. Information

Substance Name: Deoxyribonuclease I

Registry Number: EC 3.1.21.1

Grant and Affiliation Information for Transcriptional regulation of the Drosophila melanogaster muscle myosin heavy-chain gene.

AFFILIATION: Department of Biology and Molecular Biology Institute, San Diego State University, San Diego, CA 92182-4614, USA.

Country: Netherlands

AGENCY: United States NIGMS

GRANT: GM32443

ACRONYM: GM

MEDLINETA: Gene Expr Patterns

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