Transcriptional interference: an unexpected layer of complexity in gene regulation.

Transcriptional interference: an unexpected layer of complexity in gene regulation. Research Abstract Details 

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Transcriptional interference: an unexpected layer of complexity in gene regulation. Abstract Text:

Alexander Mazo,Jacob W Hodgson,Svetlana Petruk,Yurii Sedkov,Hugh W Brock,

Much of the genome is transcribed into long untranslated RNAs, mostly of unknown function. Growing evidence suggests that transcription of sense and antisense untranslated RNAs in eukaryotes can repress a neighboring gene by a phenomenon termed transcriptional interference. Transcriptional interference by the untranslated RNA may prevent recruitment of the initiation complex or prevent transcriptional elongation. Recent work in yeast, mammals, and Drosophila highlights the diverse roles that untranslated RNAs play in development. Previously, untranslated RNAs of the bithorax complex of Drosophila were proposed to be required for its activation. Recent studies show that these untranslated RNAs in fact silence Ultrabithorax in early embryos, probably by transcriptional interference.

Transcriptional interference: an unexpected layer of complexity in gene regulation. Publishing Authors By Initials

A Mazo,JW Hodgson,S Petruk,Y Sedkov,HW Brock,

For similar genetic processes: gene expression: transcription, genetic research abstracts see: genetic processes: gene expression: transcription, genetic research

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Transcriptional interference: an unexpected layer of complexity in gene regulation. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of cell science

VOLUME: 120

Page Numbers: 2755-61

Journal Abbreviation: J. Cell. Sci.

ISSN: 0021-9533

DAY: 15

MONTH: Aug

YEAR: 2007

Transcriptional interference: an unexpected layer of complexity in gene regulation. Information

Number of References: 63

LANGUAGE: eng

NlmUniqueID: 52457

Transcriptional interference: an unexpected layer of complexity in gene regulation. Keywords Mesh Terms:

KEYWORDS: Transcription, Genetic

MESH TERMS: genetics

Chemical & Substance for Abstract: Transcriptional interference: an unexpected layer of complexity in gene regulation. Information

Substance Name: RNA, Untranslated

Registry Number: 0

Grant and Affiliation Information for Transcriptional interference: an unexpected layer of complexity in gene regulation.

AFFILIATION: Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

Country: England

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MEDLINETA: J Cell Sci

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