Transcriptional control of Notch signaling by a HOX and a PBX/EXD protein during vulval development in C. elegans.

Transcriptional control of Notch signaling by a HOX and a PBX/EXD protein during vulval development in C. elegans. Research Abstract Details 

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Transcriptional control of Notch signaling by a HOX and a PBX/EXD protein during vulval development in C. elegans. Abstract Text:

Krisztina ,Tibor Vellai,Estella B Chen,Yue Zhang, Guerry,Michael J Stern,Fritz ,

The Notch signaling pathway controls growth, differentiation and patterning in divergent animal phyla; in humans, defective Notch signaling has been implicated in cancer, stroke and neurodegenerative disorders. Despite its developmental and medical significance, little is known about the factors that render cells to become competent for Notch signaling. Here we show that during vulval development in the nematode Caenorhabditis elegans the HOX protein LIN-39 and its EXD/PBX-like cofactor CEH-20 are required for LIN-12/Notch-mediated lateral signaling that specifies the 2 degrees vulval cell fate. Inactivation of either lin-39 or ceh-20 resulted in the misspecification of 2 degrees vulval cells and suppressed the multivulva phenotype of lin-12(n137) gain-of-function mutant animals. Furthermore, both LIN-39 and CEH-20 are required for the expression of basal levels of the genes encoding the LIN-12/Notch receptor and one of its ligands in the vulval precursor cells, LAG-2/Delta/Serrate, rendering them competent for the subsequent lin-12/Notch induction events. Our results suggest that the transcription factors LIN-39 and CEH-20, which function at the bottom of the RTK/Ras and Wnt pathways in vulval induction, serve as major integration sites in coordinating and transmitting signals to the LIN-12/Notch cascade to regulate vulval cell fates.

Transcriptional control of Notch signaling by a HOX and a PBX/EXD protein during vulval development in C. elegans. Publishing Authors By Initials

K ,T Vellai,EB Chen,Y Zhang,F Guerry,MJ Stern,F ,

For similar urogenital system: genitalia: genitalia, female: vulva research abstracts see: urogenital system: genitalia: genitalia, female: vulva research

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Transcriptional control of Notch signaling by a HOX and a PBX/EXD protein during vulval development in C. elegans. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Developmental biology

VOLUME: 302

Page Numbers: 661-9

Journal Abbreviation: Dev. Biol.

ISSN: 0012-1606

DAY: 4

MONTH: 10

YEAR: 2006

Transcriptional control of Notch signaling by a HOX and a PBX/EXD protein during vulval development in C. elegans. Information

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LANGUAGE: eng

NlmUniqueID: 372762

Transcriptional control of Notch signaling by a HOX and a PBX/EXD protein during vulval development in C. elegans. Keywords Mesh Terms:

KEYWORDS: Vulva

MESH TERMS: physiology

Chemical & Substance for Abstract: Transcriptional control of Notch signaling by a HOX and a PBX/EXD protein during vulval development in C. elegans. Information

Substance Name: lin-39 protein, C elegans

Registry Number: 0

Grant and Affiliation Information for Transcriptional control of Notch signaling by a HOX and a PBX/EXD protein during vulval development in C. elegans.

AFFILIATION: Department of Genetics, Eötvös Loránd University, Budapest, H-1117, Hungary.

Country: United States

AGENCY: United States NIGMS

GRANT: GM50504

ACRONYM: GM

MEDLINETA: Dev Biol

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