Transcriptional control of megakaryocyte development.

Transcriptional control of megakaryocyte development. Research Abstract Details 

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Transcriptional control of megakaryocyte development. Abstract Text:

A N Goldfarb,

Megakaryocytes are highly specialized cells that arise from a bipotent megakaryocytic-erythroid progenitor (MEP). This developmental leap requires coordinated activation of megakaryocyte-specific genes, radical changes in cell cycle properties, and active prevention of erythroid differentiation. These programs result from upregulation of megakaryocyte-selective transcription factors, downregulation of erythroid-selective transcription factors and ongoing mediation of common erythro-megakaryocytic transcription factors. Unlike most developmental programs, no single lineage-unique family of master regulators exerts executive control over the megakaryocytic plan. Rather, an assemblage of non-unique factors and signals converge to determine lineage and differentiation. In human megakaryopoiesis, hereditary disorders of platelet production have confirmed contributions from three distinct transcription factor families. Murine models have extended this repertoire to include multiple additional factors. At a mechanistic level, the means by which these non-unique factors collaborate in the establishment of a perfectly unique cell type remains a central question.

Transcriptional control of megakaryocyte development. Publishing Authors By Initials

AN Goldfarb,

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Transcriptional control of megakaryocyte development. Journal Published:

PUBLICATION TYPE: Validation Studies

Journal: Oncogene

VOLUME: 26

Page Numbers: 6795-802

Journal Abbreviation: Oncogene

ISSN: 0950-9232

DAY: 15

MONTH: Oct

YEAR: 2007

Transcriptional control of megakaryocyte development. Information

Number of References: 60

LANGUAGE: eng

NlmUniqueID: 8711562

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Grant and Affiliation Information for Transcriptional control of megakaryocyte development.

AFFILIATION: Department of Pathology, University of Virginia School of Medicine, VA 22908, USA.

Country: England

AGENCY: United States NCI

GRANT: CA93735

ACRONYM: CA

MEDLINETA: Oncogene

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