Transcriptional and post-transcriptional controls of survivin in cancer cells: novel approaches for cancer treatment.

Transcriptional and post-transcriptional controls of survivin in cancer cells: novel approaches for cancer treatment. Research Abstract Details 

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Transcriptional and post-transcriptional controls of survivin in cancer cells: novel approaches for cancer treatment. Abstract Text:

M Zhang,J Yang,F Li,

Survivin is a novel member of the inhibitor of apoptosis (IAP) protein family, and its aberrant expression in cancer cells has been shown to be associated with tumorigenesis, cancer progression, radiation/drug resistance and shorter patient survival. Survivin is also expressed in certain human adult tissues and cells, and has been shown to play a role in physiology. Interestingly, targeting survivin for cancer treatment did not show obvious toxicity to normal tissues and cells. This suggests that the mechanism for the regulation and function of survivin may actually be different in cancer cells as compared to normal cells. This review intends to summarize the most important information about the transcriptional and/or post-transcriptional controls of survivin in cancer cells. Further studies along this line may find essential interfaces for the development of novel approaches for cancer therapeutics.

Transcriptional and post-transcriptional controls of survivin in cancer cells: novel approaches for cancer treatment. Publishing Authors By Initials

M Zhang,J Yang,F Li,

For similar biological factors: biological markers: tumor markers, biological research abstracts see: biological factors: biological markers: tumor markers, biological research

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Transcriptional and post-transcriptional controls of survivin in cancer cells: novel approaches for cancer treatment. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of experimental & clinical cancer research

VOLUME: 25

Page Numbers: 391-402

Journal Abbreviation: J. Exp. Clin. Cancer Res.

ISSN: 0392-9078

DAY: 3

MONTH: Sep

YEAR: 2006

Transcriptional and post-transcriptional controls of survivin in cancer cells: novel approaches for cancer treatment. Information

Number of References: 79

LANGUAGE: eng

NlmUniqueID: 8308647

Transcriptional and post-transcriptional controls of survivin in cancer cells: novel approaches for cancer treatment. Keywords Mesh Terms:

KEYWORDS: Tumor Markers, Biological

MESH TERMS: metabolism

Chemical & Substance for Abstract: Transcriptional and post-transcriptional controls of survivin in cancer cells: novel approaches for cancer treatment. Information

Substance Name: Tumor Markers, Biological

Registry Number: 0

Grant and Affiliation Information for Transcriptional and post-transcriptional controls of survivin in cancer cells: novel approaches for cancer treatment.

AFFILIATION: Cancer Institute and School of Life Science & Technology, Tongji University, Shanghai, China.

Country: Italy

AGENCY: United States NCI

GRANT: R01 CA109481

ACRONYM: CA

MEDLINETA: J Exp Clin Cancer Res

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