Transcriptional and epigenetic regulation of interleukin-2 gene in activated T cells by morphine.

Transcriptional and epigenetic regulation of interleukin-2 gene in activated T cells by morphine. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Transcriptional and epigenetic regulation of interleukin-2 gene in activated T cells by morphine. Abstract Text:

Jinghua Wang,Roderick A Barke,Sabita Roy,

Chronic morphine inhibits interleukin-2 (IL-2) at both the transcriptional and protein synthesis levels. The molecular mechanisms by which morphine decreases IL-2 are not fully understood. The production of IL-2 is tightly regulated by several transcription factors that bind to the IL-2 promoter. Herein, we show that chronic morphine treatment results in an increase in cAMP levels with a concurrent up-regulation of the cAMP inducible repressor inducible cAMP early repressor (ICER)/cAMP response element modulator (CREM) and down-regulation of p-cAMP-response element-binding protein (CREB) in activated T cells. Furthermore, ICER competes for p-CREB binding to the cAMP-responsive elements (CREs) site. This leads to the uncoupling of CBP/p300 thereby abrogating IL-2 transcription. Overexpression of either antisense CREM or CREB plasmid rescued morphine-induced inhibition of IL-2 promoter activity and protein production. In addition, we also found that chronic morphine treatment inhibited the acetylation and trimethylation of histones and decreased both DNA demethylation and accessibility of the IL-2 promoter. These findings suggest that chronic morphine treatment may function through both transcriptional and epigenetic mechanisms to inhibit IL-2 production.

Transcriptional and epigenetic regulation of interleukin-2 gene in activated T cells by morphine. Publishing Authors By Initials

J Wang,RA Barke,S Roy,

For similar enzymes and coenzymes: enzymes: transferases: acyltransferases: acetyltransferases: p300-cbp transcription factors research abstracts see: enzymes and coenzymes: enzymes: transferases: acyltransferases: acetyltransferases: p300-cbp transcription factors research

PUBMED ID PMID:

MEDLINE DATE:

Transcriptional and epigenetic regulation of interleukin-2 gene in activated T cells by morphine. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The Journal of biological chemistry

VOLUME: 282

Page Numbers: 7164-71

Journal Abbreviation: J. Biol. Chem.

ISSN: 0021-9258

DAY: 16

MONTH: 01

YEAR: 2007

Transcriptional and epigenetic regulation of interleukin-2 gene in activated T cells by morphine. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985121

Transcriptional and epigenetic regulation of interleukin-2 gene in activated T cells by morphine. Keywords Mesh Terms:

KEYWORDS: p300-CBP Transcription Factors

MESH TERMS: metabolism

Chemical & Substance for Abstract: Transcriptional and epigenetic regulation of interleukin-2 gene in activated T cells by morphine. Information

Substance Name: p300-CBP Transcription Factors

Registry Number: EC 2.3.1.48

Grant and Affiliation Information for Transcriptional and epigenetic regulation of interleukin-2 gene in activated T cells by morphine.

AFFILIATION: Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota 55455, USA.

Country: United States

AGENCY: United States NIDA

GRANT: T32DA07097

ACRONYM: DA

MEDLINETA: J Biol Chem

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Transcriptional and epigenetic regulation of interleukin-2 gene in activated T cells by morphine Related Publications

• A novel range based QSAR study of human neuropeptide Y (NPY) Y5 receptor inhibitors.
• Assembly of feline calicivirus-like particle and its immunogenicity.
• Calotropis procera latex extract affords protection against inflammation and oxidative stress in Freund's complete adjuvant-induced monoarthritis in rats.
• Community eye health care for leprosy patients in west bengal, India.
• Comparative protein modeling and surface analysis of Leishmania sirtuin: A potential target for antileishmanial drug discovery.
• Development of primordial follicles in the hamster: role of estradiol-17beta.
• Effector proteins translocated by Legionella pneumophila: strength in numbers.
• Emotional distress in women presenting for breast imaging.
• Enhancing antitumor immunity: combining IL-12 with TGFbeta1 antagonism.
• Evaluation of the clinical decisions made for 2-year-olds referred for speech and language therapy: a follow-up study.
• Explosive Force Production and Fractionated Reaction Time in Elderly Low and High Active Women: 974: June 2 10:45 AM - 11:00 AM.
• Explosive force and fractionated reaction time in elderly low- and high-active women.
• Expression of G protein-coupled receptor 30 in the hamster ovary: differential regulation by gonadotropins and steroid hormones.
• Glossal angiomyoma: Imaging findings and endovascular treatment.
• Glycemic control in critically ill patients effect of delay in insulin administration.
• Harlequin fetus.
• Magnesium, essential for base excision repair enzymes, inhibits substrate binding of N-methylpurine-DNA glycosylase.
• Molecular mechanism of insulin resistance.
• Opposing functions of TFII-I spliced isoforms in growth factor-induced gene expression.
• Oxidative DNA damage repair in mammalian cells: a new perspective.
• Perceived hyperoxia: oxygen-induced remodeling of the reoxygenated heart.
• Profiles and correlates of aggressive behaviour among adults with intellectual disabilities.
• Six-year incidence of proteinuria in type 1 diabetic African Americans.
• Surface plasmon resonance as a time-resolved probe of structural changes in molecular films: considerations for correlating resonance shifts with adsorbate layer parameters.
• Survey of clinical engineering in developing countries and model for technology acquisition and diffusion.
• Technical aspects of online hemodiafiltration.
• Tocotrienols: the emerging face of natural vitamin E.
• Transcriptional and epigenetic regulation of interleukin-2 gene in activated T cells by morphine.
• Where people die: a multilevel approach to understanding influences on site of death in America.
• miRNA: licensed to kill the messenger.