Transcription factor Sp4 regulates dendritic patterning during cerebellar maturation.

Transcription factor Sp4 regulates dendritic patterning during cerebellar maturation. Research Abstract Details 

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Transcription factor Sp4 regulates dendritic patterning during cerebellar maturation. Abstract Text:

Ramos,Brice ,Azad Bonni,Grace Gill, Ramos,Brice ,Azad Bonni,Grace Gill,

Integration of inputs by a neuron depends on dendritic arborization patterns. In mammals, the genetic programs that regulate dynamic remodeling of dendrites during development and in response to activity are incompletely understood. Here we report that knockdown of the transcription factor Sp4 led to an increased number of highly branched dendrites during maturation of cerebellar granule neurons in dissociated cultures and in cerebellar cortex. Time-course analysis revealed that depletion of Sp4 led to persistent generation of dendritic branches and a failure in resorption of transient dendrites. Depolarization induced a reduction in the number of dendrites, and knockdown of Sp4 blocked depolarization-induced remodeling. Furthermore, overexpression of Sp4 wild type, but not a mutant lacking the DNA-binding domain, was sufficient to promote dendritic pruning in nondepolarizing conditions. These findings indicate that the transcription factor Sp4 controls dendritic patterning during cerebellar development by limiting branch formation and promoting activity-dependent pruning.

Transcription factor Sp4 regulates dendritic patterning during cerebellar maturation. Publishing Authors By Initials

B Ramos,B ,A Bonni,G Gill,B Ramos,B ,A Bonni,G Gill,

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Transcription factor Sp4 regulates dendritic patterning during cerebellar maturation. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 104

Page Numbers: 9882-7

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 0027-8424

DAY: 29

MONTH: 05

YEAR: 2007

Transcription factor Sp4 regulates dendritic patterning during cerebellar maturation. Information

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LANGUAGE: eng

NlmUniqueID: 7505876

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Grant and Affiliation Information for Transcription factor Sp4 regulates dendritic patterning during cerebellar maturation.

AFFILIATION: Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

Country: United States

AGENCY: United States NINDS

GRANT: NS051255

ACRONYM: NS

MEDLINETA: Proc Natl Acad Sci U S A

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• Transcription factor Sp4 regulates dendritic patterning during cerebellar maturation.