Transcranial direct current stimulation reveals inhibitory deficiency in migraine.

Transcranial direct current stimulation reveals inhibitory deficiency in migraine. Research Abstract Details 

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Transcranial direct current stimulation reveals inhibitory deficiency in migraine. Abstract Text:

Z Chadaide,S Arlt,A Antal,M A Nitsche,N Lang,W Paulus,

The issue of interictal excitability of cortical neurons in migraine patients is controversial: some studies have reported hypo-, others hyperexcitability. The aim of the present study was to observe the dynamics of this basic interictal state by further modulating the excitability level of the visual cortex using transcranial direct current stimulation (tDCS) in migraineurs with and without aura. In healthy subjects anodal tDCS decreases, cathodal stimulation increases transcranial magnetic stimulation (TMS)-elicited phosphene thresholds (PT), which is suggested as a representative value of visual cortex excitability. Compared with healthy controls, migraine patients tended to show lower baseline PT values, but this decrease failed to reach statistical significance. Anodal stimulation decreased phosphene threshold in migraineurs similarly to controls, having a larger effect in migraineurs with aura. Cathodal stimulation had no significant effect in the patient groups. This result strengthens the notion of deficient inhibitory processes in the cortex of migraineurs, which is selectively revealed by activity-modulating cortical input.

Transcranial direct current stimulation reveals inhibitory deficiency in migraine. Publishing Authors By Initials

Z Chadaide,S Arlt,A Antal,MA Nitsche,N Lang,W Paulus,

For similar nervous system: central nervous system: brain: prosencephalon: telencephalon: cerebrum: cerebral cortex: occipital lobe: visual cortex research abstracts see: nervous system: central nervous system: brain: prosencephalon: telencephalon: cerebrum: cerebral cortex: occipital lobe: visual cortex research

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Transcranial direct current stimulation reveals inhibitory deficiency in migraine. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cephalalgia : an international journal of headache

VOLUME: 27

Page Numbers: 833-9

Journal Abbreviation: Cephalalgia

ISSN: 0333-1024

DAY: 10

MONTH: 05

YEAR: 2007

Transcranial direct current stimulation reveals inhibitory deficiency in migraine. Information

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LANGUAGE: eng

NlmUniqueID: 8200710

Transcranial direct current stimulation reveals inhibitory deficiency in migraine. Keywords Mesh Terms:

KEYWORDS: Visual Cortex

MESH TERMS: physiopathology

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Grant and Affiliation Information for Transcranial direct current stimulation reveals inhibitory deficiency in migraine.

AFFILIATION: Department of Clinical Neurophysiology, Georg-August University, Göttingen, Germany.

Country: England

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MEDLINETA: Cephalalgia

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