Transactivation of the IGF-1R by aldosterone.

Transactivation of the IGF-1R by aldosterone. Research Abstract Details 

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Transactivation of the IGF-1R by aldosterone. Abstract Text:

Jennifer L Holzman,Lian Liu,Billie Jeanne Duke,Alexandra E Kemendy,Douglas C Eaton,

Activation of epithelial sodium channels (ENaC) by aldosterone, insulin, or insulin-like growth factor-1 (IGF-1) in renal epithelial cells (including the Xenopus laevis renal cell line A6) appears to share some common signaling elements subsequent to the initial insulin or IGF-1 receptor activation. Previously, the convergence point for insulin or IGF-1 and aldosterone signaling was assumed to be downstream of the receptor at the level of phosphatidylinositol 3-kinase (PI3-K); however, this study shows aldosterone directly transactivates the IGF-1 receptor (IGF-1R). In A6 cells, 10-min exposure to aldosterone increased the phosphorylation of the IGF-1 receptor, insulin receptor substrate-1 (IRS-1), and Akt (PKB). Furthermore, aldosterone activated PI3-K and phosphorylation of the most downstream element, Akt, was blocked by the specific PI3-K inhibitor LY-294002. Transactivation requires aldosterone binding to the mineralocorticoid/glucocorticoid receptor and does not require transcription.

Transactivation of the IGF-1R by aldosterone. Publishing Authors By Initials

JL Holzman,L Liu,BJ Duke,AE Kemendy,DC Eaton,

For similar animals: chordata: vertebrates: amphibia: anura: pipidae: xenopus: xenopus laevis research abstracts see: animals: chordata: vertebrates: amphibia: anura: pipidae: xenopus: xenopus laevis research

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Transactivation of the IGF-1R by aldosterone. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: American journal of physiology. Renal physiology

VOLUME: 292

Page Numbers: F1219-28

Journal Abbreviation:

ISSN: 0363-6127

DAY: 26

MONTH: 12

YEAR: 2006

Transactivation of the IGF-1R by aldosterone. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100901990

Transactivation of the IGF-1R by aldosterone. Keywords Mesh Terms:

KEYWORDS: Xenopus laevis

MESH TERMS: drug effects

Chemical & Substance for Abstract: Transactivation of the IGF-1R by aldosterone. Information

Substance Name: Proto-Oncogene Proteins c-akt

Registry Number: EC 2.7.1.37

Grant and Affiliation Information for Transactivation of the IGF-1R by aldosterone.

AFFILIATION: Emory Univ. School of Medicine, Dept. of Medicine, Renal Div., 1639 Pierce Dr., Rm. 3327, Atlanta, GA 30322, USA. jennifer.holzman@emory.edu

Country: United States

AGENCY: United States NIDDK

GRANT: R37-DK-037963

ACRONYM: DK

MEDLINETA: Am J Physiol Renal Physiol

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