Trans-fatty acid intake and increased risk of advanced prostate cancer: modification by RNASEL R462Q variant.

Trans-fatty acid intake and increased risk of advanced prostate cancer: modification by RNASEL R462Q variant. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Trans-fatty acid intake and increased risk of advanced prostate cancer: modification by RNASEL R462Q variant. Abstract Text:

Xin Liu,Fredrick R Schumacher,Sarah J Plummer,Eric Jorgenson,Graham Casey,John S Witte,

Previous studies have examined the role of higher trans-fatty acid consumption on prostate cancer risk, but the results remain unclear. Any potential association may be modified by variants in genes involved with immune and inflammatory responses. To investigate this, we undertook a case-control study (N = 1012) of the association between trans-fatty acid intake and advanced prostate cancer, and evaluated whether this effect was modified by a functional polymorphism in the RNASEL gene (R462Q). Among Caucasians (N = 834), we observed that each type of trans-fatty acid and total trans-fatty acid intake showed a statistically significant positive association with prostate cancer, but only weakly increased risk for the isomers of cis-fatty acids. Compared with the lowest quartile of total trans-fatty acid consumption, the higher quartiles gave odds ratios (ORs) equal to 1.58 [95% confidence interval (CI): 1.00, 2.48], 1.95 (95% CI: 1.20, 3.19) and 2.77 (95% CI: 1.60, 4.79) (P-trend = 0.0003); this effect was modified by the RNASEL R462Q polymorphism (P(interaction) = 0.01). Among men with the QQ/RQ genotype, the association between total trans-fatty acid intake and prostate cancer was substantially stronger [ORs of higher quartiles equal to 2.93 (95% CI: 1.62, 5.30), 3.13 (95% CI: 1.64, 5.98) and 4.80 (95% CI: 2.29, 10.08), respectively]. For men with the RR genotype, total trans-fatty acid intake was not associated with disease. This suggests that among Caucasians, positive association between higher trans-fatty acid consumption and prostate cancer may be modified by the functional RNASEL variant R462Q.

Trans-fatty acid intake and increased risk of advanced prostate cancer: modification by RNASEL R462Q variant. Publishing Authors By Initials

X Liu,FR Schumacher,SJ Plummer,E Jorgenson,G Casey,JS Witte,

For similar lipids: fatty acids: fatty acids, unsaturated: trans fatty acids research abstracts see: lipids: fatty acids: fatty acids, unsaturated: trans fatty acids research

PUBMED ID PMID:

MEDLINE DATE:

Trans-fatty acid intake and increased risk of advanced prostate cancer: modification by RNASEL R462Q variant. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Carcinogenesis

VOLUME: 28

Page Numbers: 1232-6

Journal Abbreviation: Carcinogenesis

ISSN: 0143-3334

DAY: 18

MONTH: 01

YEAR: 2007

Trans-fatty acid intake and increased risk of advanced prostate cancer: modification by RNASEL R462Q variant. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8008055

Trans-fatty acid intake and increased risk of advanced prostate cancer: modification by RNASEL R462Q variant. Keywords Mesh Terms:

KEYWORDS: Trans Fatty Acids

MESH TERMS: physiology

Chemical & Substance for Abstract: Trans-fatty acid intake and increased risk of advanced prostate cancer: modification by RNASEL R462Q variant. Information

Substance Name: pppA(2'p5'A)n-dependent ribonuclease

Registry Number: EC 3.1.26.-

Grant and Affiliation Information for Trans-fatty acid intake and increased risk of advanced prostate cancer: modification by RNASEL R462Q variant.

AFFILIATION: Department of Epidemiology and Biostatistics and Institute for Human Genetics, University of California, San Francisco, CA 94143-0794, USA.

Country: England

AGENCY: United States NCI

GRANT: CA98683

ACRONYM: CA

MEDLINETA: Carcinogenesis

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Trans-fatty acid intake and increased risk of advanced prostate cancer: modification by RNASEL R462Q variant Related Publications

• Association of testis derived transcript gene variants and prostate cancer risk.
• COX2 genetic variation, NSAIDs, and advanced prostate cancer risk.
• Enhanced Paracrine FGF10 Expression Promotes Formation of Multifocal Prostate Adenocarcinoma and an Increase in Epithelial Androgen Receptor.
• Enriching the analysis of genomewide association studies with hierarchical modeling.
• Immunoglobulin-like transcripts as risk genes for autoimmunity.
• Isolation and functional characterization of murine prostate stem cells.
• Landmarks and advances in translational lymphology.
• MIC1 and IL1RN genetic variation and advanced prostate cancer risk.
• Model-related analysis of EEG burst patterns in sedated patients.
• Multiple prostate cancer risk variants on 8q24.
• Nonsteroidal antiinflammatory drugs and decreased risk of advanced prostate cancer: modification by lymphotoxin alpha.
• Occurrence of the USA300 community-acquired Staphylococcus aureus clone in Austria.
• Plasma cell purification from murine bone marrow using a two-step isolation approach.
• Positron emission tomography with computed tomography imaging of neuroinflammation in experimental autoimmune encephalomyelitis.
• Report of a case of acute hydramnios.
• Self-renewal and multilineage differentiation in vitro from murine prostate stem cells.
• Sensor, signal, and image informatics - state of the art and current topics.
• Sustained suppression of Bcr-Abl-driven lymphoid leukemia by microRNA mimics.
• Temporal characterization of short-pulse third-harmonic generation in an atomic gas by a transmission-grating Michelson interferometer.
• The effect of regional gene therapy with bone morphogenetic protein-2-producing bone-marrow cells on the repair of segmental femoral defects in rats.
• The effects of microenvironment and internal programming on plasma cell survival.
• Time-variant analysis of nonlinear stability and bispectral measures to quantify the development of fetal sleep States.
• Time-variant parametric estimation of transient quadratic phase couplings between heart rate components in healthy neonates.
• Toll-like receptor 4 genetic variation and advanced prostate cancer risk.
• Trans-fatty acid intake and increased risk of advanced prostate cancer: modification by RNASEL R462Q variant.
• Vitamin D receptor genotypes/haplotypes and prostate cancer risk.
• [In Process Citation]
• [In Process Citation]
• [Not Available.]
• [Premedication, preoperative and postoperative visits : Importance as reflected in anaesthesiology textbooks.]