Tramtrack69 interacts with the dMi-2 subunit of the Drosophila NuRD chromatin remodelling complex.

Tramtrack69 interacts with the dMi-2 subunit of the Drosophila NuRD chromatin remodelling complex. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Tramtrack69 interacts with the dMi-2 subunit of the Drosophila NuRD chromatin remodelling complex. Abstract Text:

dMi-2, the ATPase subunit of the Drosophila nucleosome remodelling and histone deacetylation (dNuRD) complex, was identified in a two-hybrid screen as an interacting partner of the transcriptional repressor, Tramtrack69 (Ttk69). A short region of Ttk69 is sufficient to mediate this interaction. Ttk69, but not the Ttk88 isoform, co-purifies with the dNuRD complex isolated from embryo extracts. dMi-2 and Ttk69 co-immunoprecipitate from embryonic extracts, indicating that they can associate in vivo. Both dMi-2 and Ttk69 co-localize at a number of discrete sites on polytene chromosomes, showing that they bind common target loci. We also demonstrate that dMi-2 and Ttk interact genetically, indicating a functional interaction in vivo. We propose that Ttk69 represses some target genes by remodelling chromatin structure through the recruitment of the dNuRD complex.

Tramtrack69 interacts with the dMi-2 subunit of the Drosophila NuRD chromatin remodelling complex. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Tramtrack69 interacts with the dMi-2 subunit of the Drosophila NuRD chromatin remodelling complex. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: EMBO reports

VOLUME: 2

Page Numbers: 1089-94

Journal Abbreviation: EMBO Rep.

ISSN: 1469-221X

DAY: 21

MONTH: 11

YEAR: 2001

Tramtrack69 interacts with the dMi-2 subunit of the Drosophila NuRD chromatin remodelling complex. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100963049

Tramtrack69 interacts with the dMi-2 subunit of the Drosophila NuRD chromatin remodelling complex. Keywords Mesh Terms:

KEYWORDS: Yeasts

MESH TERMS: metabolism

Chemical & Substance for Abstract: Tramtrack69 interacts with the dMi-2 subunit of the Drosophila NuRD chromatin remodelling complex. Information

Substance Name: Adenosine Triphosphatases

Registry Number: EC 3.6.1.-

Grant and Affiliation Information for Tramtrack69 interacts with the dMi-2 subunit of the Drosophila NuRD chromatin remodelling complex.

AFFILIATION: MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: EMBO Rep

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Tramtrack69 interacts with the dMi-2 subunit of the Drosophila NuRD chromatin remodelling complex Related Publications

• A Drosophila Smyd4 homologue is a muscle-specific transcriptional modulator involved in development.
• A variable topology for the 30-nm chromatin fibre.
• Activation of platelet-activating factor receptor in SZ95 sebocytes results in inflammatory cytokine and prostaglandin E2 production.
• An assessment of toxicity in profundal lake sediment due to deposition of heavy metals and persistent organic pollutants from the atmosphere.
• Case report: thyroid hormone resistance and its therapeutic challenges.
• Contrast-medium-induced electrocardiographic abnormalities: comparison of bolus and infusion of methylglucamine iodamide and methylglucamine/sodium diatrizoate.
• Current incidence of N-nitrosodimethylamine in beers worldwide.
• Differential effects of aging on processes underlying task switching.
• Does this patient meet the criteria for emergency severity index level 2?
• Double-blind clinical trial of topical steroids in anterior uveitis.
• High-affinity DNA binding sites for H-NS provide a molecular basis for selective silencing within proteobacterial genomes.
• Identification of the HLA-DM/HLA-DR interface.
• Involvement of P38 MAP kinase in the augmentation of UVB-mediated apoptosis via the epidermal platelet-activating factor receptor.
• Licking and gaping elicited by microstimulation of the nucleus of the solitary tract.
• Moxifloxacin-associated drug hypersensitivity syndrome with toxic epidermal necrolysis and fulminant hepatic failure.
• Perforation of intestine by fishbone.
• Reflex topography in the nucleus of the solitary tract.
• SUPPRESSION OF VISION IN SQUINT AND ITS ASSOCIATION WITH RETINAL CORRESPONDENCE AND AMBLYOPIA.
• Single neurons in the nucleus of the solitary tract respond selectively to bitter taste stimuli.
• Supercontinuum generation in a water-core photonic crystal fiber.
• THE ORIGIN OF ABNORMAL RETINAL CORRESPONDENCE.
• Taste-evoked Fos expression in nitrergic neurons in the nucleus of the solitary tract and reticular formation of the rat.
• The chromatin remodelling factor dATRX is involved in heterochromatin formation.
• Tracking the temporal dynamics of updating cognitive control: an examination of error processing.
• Tramtrack69 interacts with the dMi-2 subunit of the Drosophila NuRD chromatin remodelling complex.
• Two modes of degradation of the tramtrack transcription factors by siah homologues.
• UVB radiation-mediated inhibition of contact hypersensitivity reactions is dependent on the platelet-activating factor system.