Trafficking of Alzheimer's disease-related membrane proteins and its participation in disease pathogenesis.

Trafficking of Alzheimer's disease-related membrane proteins and its participation in disease pathogenesis. Research Abstract Details 

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Trafficking of Alzheimer's disease-related membrane proteins and its participation in disease pathogenesis. Abstract Text:

Toshiharu Suzuki,Yoichi Araki,Tohru Yamamoto,Tadashi Nakaya,

Alzheimer's disease (AD) is a common neurodegenerative disorder that causes senile dementia. The pathological characteristics are the appearance of neurofibrillary tangles comprising abnormally phosphorylated tau and senile plaques composed of amyloid beta-protein depositions. Amyloid beta-protein precursor (APP) and presenilin (PS) are known to be causative genes of familial AD. Recent analyses have documented that APP functions in the axonal transport of vesicles and PS regulates intracellular protein trafficking. Dystrophic neurites, in which APP and Alcadein accumulate in swollen axons, are also observed in AD brain. These pathological characteristics and the features of AD-related proteins suggest that AD is a disease of the vesicular transport system. Here we review recent progress of research on AD pathogenesis from the viewpoint of membrane trafficking.

Trafficking of Alzheimer's disease-related membrane proteins and its participation in disease pathogenesis. Publishing Authors By Initials

T Suzuki,Y Araki,T Yamamoto,T Nakaya,

For similar nervous system: neurons: senile plaques research abstracts see: nervous system: neurons: senile plaques research

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Trafficking of Alzheimer's disease-related membrane proteins and its participation in disease pathogenesis. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of biochemistry

VOLUME: 139

Page Numbers: 949-55

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Jun

YEAR: 2006

Trafficking of Alzheimer's disease-related membrane proteins and its participation in disease pathogenesis. Information

Number of References: 51

LANGUAGE: eng

NlmUniqueID: 376600

Trafficking of Alzheimer's disease-related membrane proteins and its participation in disease pathogenesis. Keywords Mesh Terms:

KEYWORDS: Senile Plaques

MESH TERMS: pathology

Chemical & Substance for Abstract: Trafficking of Alzheimer's disease-related membrane proteins and its participation in disease pathogenesis. Information

Substance Name: Nerve Tissue Proteins

Registry Number: 0

Grant and Affiliation Information for Trafficking of Alzheimer's disease-related membrane proteins and its participation in disease pathogenesis.

AFFILIATION: Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12-Nishi 6, Kita-ku, Sapporo 060-0812. tsuzuki@pharm.hokudai.ac.jp

Country: Japan

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MEDLINETA: J Biochem

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