TRAF4 is potently induced by TAp63 isoforms and localised according to differentiation in SCCHN.

TRAF4 is potently induced by TAp63 isoforms and localised according to differentiation in SCCHN. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

TRAF4 is potently induced by TAp63 isoforms and localised according to differentiation in SCCHN. Abstract Text:

p63, a member of the p53 family, is overexpressed in squamous cell carcinoma of the head and neck (SCCHN) and some other tumors of epithelial origin. As a transcription factor, p63 can bind to p53-type response elements and there is some overlap between p53 family transcriptional targets. Tumor necrosis factor receptor associated factor 4 (TRAF4) is a p53 regulated gene which is overexpressed in many human carcinomas. We investigated the involvement of p63 in regulation of TRAF4 and the expression of the TRAF4 protein in SCCHN. Disrupting endogenous p63 expression resulted in downregulation of TRAF4 mRNA and protein in an SCCHN cell line. Endogenous p63 bound to the TRAF4 promoter in vivo and reporter assays showed that p63, p73 and p53 can all transactivate TRAF4, with TAp63 isoforms being the most potent activators. The level of TRAF4 activation by TAp63 was two-fold higher than by p53, and TRAF4 was ten-fold more responsive to TAp63 than another p63-target, IGFBP3. Nuclear expression of TRAF4 was seen in normal oral epithelium and highly/moderately differentiated SCCHN, whereas cytoplasmic expression of TRAF4 was seen in poorly differentiated SCCHN. These results indicate that TRAF4 is a common target of p53 family members and that localization of TRAF4 is associated with differentiation of SCCHN cells.

TRAF4 is potently induced by TAp63 isoforms and localised according to differentiation in SCCHN. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

TRAF4 is potently induced by TAp63 isoforms and localised according to differentiation in SCCHN. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cancer biology & therapy

VOLUME: 6

Page Numbers: 1986-90

Journal Abbreviation: Cancer Biol. Ther.

ISSN: 1555-8576

DAY: 8

MONTH: 09

YEAR: 2007

TRAF4 is potently induced by TAp63 isoforms and localised according to differentiation in SCCHN. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101137842

TRAF4 is potently induced by TAp63 isoforms and localised according to differentiation in SCCHN. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: TRAF4 is potently induced by TAp63 isoforms and localised according to differentiation in SCCHN. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for TRAF4 is potently induced by TAp63 isoforms and localised according to differentiation in SCCHN.

AFFILIATION: Department of Medical Biosciences/Pathology, Umeå University, Umeå, Sweden.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Cancer Biol Ther

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

TRAF4 is potently induced by TAp63 isoforms and localised according to differentiation in SCCHN Related Publications

• A 10-year prospective follow-up study of 2268 cases at the child guidance clinics in Stockholm.
• A 20-year prospective follow-up study of 2 164 cases at the child guidance clinics in Stockholm.
• Acute venous thrombosis after pancreas transplantation: diagnosis with duplex Doppler sonography and scintigraphy.
• Biosocial aspects of multiple births.
• Breastfeeding in phenylketonuria.
• Children of alcoholic fathers.
• Chlamydia trachomatis in the Throat: Is Testing Necessary?
• Comparative study of the effect of luminal hypotonicity on mucosal permeability in rat upper gastrointestinal tract.
• Decreased expression of the p63 related proteins beta-catenin, E-cadherin and EGFR in oral lichen planus.
• DeltaNp63 isoforms regulate CD44 and keratins 4, 6, 14 and 19 in squamous cell carcinoma of head and neck.
• Effect of fengycin, a lipopeptide produced by Bacillus subtilis, on model biomembranes.
• Effects of some opiates and vasoactive intestinal peptide (VIP) on duodenal surface epithelial bicarbonate secretion in the rat.
• Endogenous p63 acts as a survival factor for tumour cells of SCCHN origin.
• Expression of novel p53 isoforms in oral lichen planus.
• Expression of p63, COX-2, EGFR and beta-catenin in smokers and patients with squamous cell carcinoma of the head and neck reveal variations in non-neoplastic tissue and no obvious changes in smokers.
• Identification of the gastroduodenal junction by potential difference measurements.
• Improved contact tracing for Chlamydia trachomatis with experienced tracers, tracing for one year back in time and interviewing by phone in remote areas.
• Low prevalence of smoking in patients with autism spectrum disorders.
• On the placental transfer of iron; an experimental study in the rat.
• Phlebographic diagnosis of acute deep leg thrombosis.
• Physical symptoms and psychogenic etiology; an investigation of consultation material.
• Radiological aspects of venous insufficiency.
• THYROID HORMONE ACTIVITY AND GASTROINTESTINAL FUNCTION. AN EXPERIMENTAL STUDY IN THE RAT.
• TRAF4 is potently induced by TAp63 isoforms and localised according to differentiation in SCCHN.
• The impact of postnatal environment on opioid peptides in young and adult male Wistar rats.
• The multivariate concentric square field test reveals different behavioural profiles in male AA and ANA rats with regard to risk taking and environmental reactivity.
• Thermomyces lanuginosus lipase in the liquid-crystalline phases of aqueous phytantriol: X-ray diffraction and vibrational spectroscopic studies.
• Tissue ischemia and hyperbaric oxygen treatment: an experimental study.
• Warfarin and cataract extraction.
• p63 contributes to cell invasion and migration in squamous cell carcinoma of the head and neck.