Tracking phenotypically and functionally distinct T cell subsets via T cell repertoire diversity.

Tracking phenotypically and functionally distinct T cell subsets via T cell repertoire diversity. Research Abstract Details 

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Tracking phenotypically and functionally distinct T cell subsets via T cell repertoire diversity. Abstract Text:

Katherine Kedzierska,Nicole L La Gruta,John Stambas,Stephen J Turner,Peter C Doherty,Katherine Kedzierska,Nicole L La Gruta,John Stambas,Stephen J Turner,Peter C Doherty,Katherine Kedzierska,Nicole L La Gruta,John Stambas,Stephen J Turner,Peter C Doherty,Katherine Kedzierska,Nicole L La Gruta,John Stambas,Stephen J Turner,Peter C Doherty,

Antigen-specific T cell receptors (TCRs) recognise complexes of immunogenic peptides (p) and major histocompatibility complex (MHC) glycoproteins. Responding T cell populations show profiles of preferred usage (or bias) toward one or few TCRbeta chains. Such skewing is also observed, though less commonly, in TCRalpha chain usage. The extent and character of clonal diversity within individual, antigen-specific T cell sets can be established by sequence analysis of the TCRVbeta and/or TCRValpha CDR3 loops. The present review provides examples of such TCR repertoires in prominent responses to acute and persistent viruses. The determining role of structural constraints and antigen dose is discussed, as is the way that functionally and phenotypically distinct populations can be defined at the clonal level. In addition, clonal dissection of "high" versus "low" avidity, or "central" versus "effector" memory sets provides insights into how these antigen specific T cell responses are generated and maintained. As TCR diversity potentially influences both the protective capacity of CD8(+) T cells and the subversion of immune control that leads to viral escape, analysing the spectrum of TCR selection and maintenance has implications for improving the functional efficacy of T cell responsiveness and effector function.

Tracking phenotypically and functionally distinct T cell subsets via T cell repertoire diversity. Publishing Authors By Initials

K Kedzierska,NL La Gruta,J Stambas,SJ Turner,PC Doherty,K Kedzierska,NL La Gruta,J Stambas,SJ Turner,PC Doherty,K Kedzierska,NL La Gruta,J Stambas,SJ Turner,PC Doherty,K Kedzierska,NL La Gruta,J Stambas,SJ Turner,PC Doherty,

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Tracking phenotypically and functionally distinct T cell subsets via T cell repertoire diversity. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Molecular immunology

VOLUME: 45

Page Numbers: 607-18

Journal Abbreviation: Mol. Immunol.

ISSN: 0161-5890

DAY: 24

MONTH: 08

YEAR: 2007

Tracking phenotypically and functionally distinct T cell subsets via T cell repertoire diversity. Information

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LANGUAGE: eng

NlmUniqueID: 7905289

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Grant and Affiliation Information for Tracking phenotypically and functionally distinct T cell subsets via T cell repertoire diversity.

AFFILIATION: Department of Microbiology and Immunology, University of Melbourne, Parkville 3010, Melbourne, Australia.

Country: England

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MEDLINETA: Mol Immunol

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