Toxicogenomics in drug discovery and drug development: potential applications and future challenges.

Toxicogenomics in drug discovery and drug development: potential applications and future challenges. Research Abstract Details 

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Toxicogenomics in drug discovery and drug development: potential applications and future challenges. Abstract Text:

Tin Oo Khor,Sherif Ibrahim,Ah-Ng Tony Kong,

Despite the massive investments made by pharmaceutical companies on drug research and development, the number of new drug approvals has remained stagnant in the past decades. It is well known that developing safe and effective new drugs is a long, difficult, and expensive process. While the cost of developing new drugs is increasing rapidly, withdrawals of drugs from the marketplace due to adverse drug reactions (ADR) and/or toxicity is increasing concurrently. The recent advent of high-throughput in silico (computer softwares) and in vitro (cell cultures) screenings have somewhat alleviated some, but not all, of these challenges by providing an efficient and effective way for developing safer and better drugs. This emerging technology, known as toxicogenomics, has great potential to facilitate the development of methodologies that could predict the long-term toxic effects of compounds using relatively short-term bioassays. This review is aimed at discussing the potential applications and future challenges of toxicogenomics in drug discovery and drug development.

Toxicogenomics in drug discovery and drug development: potential applications and future challenges. Publishing Authors By Initials

TO Khor,S Ibrahim,AN Kong,

For similar biological sciences: biology: genetics: pharmacogenetics: toxicogenetics research abstracts see: biological sciences: biology: genetics: pharmacogenetics: toxicogenetics research

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Toxicogenomics in drug discovery and drug development: potential applications and future challenges. Journal Published:

PUBLICATION TYPE: Review

Journal: Pharmaceutical research

VOLUME: 23

Page Numbers: 1659-64

Journal Abbreviation: Pharm. Res.

ISSN: 0724-8741

DAY: 3

MONTH: Aug

YEAR: 2006

Toxicogenomics in drug discovery and drug development: potential applications and future challenges. Information

Number of References: 56

LANGUAGE: eng

NlmUniqueID: 8406521

Toxicogenomics in drug discovery and drug development: potential applications and future challenges. Keywords Mesh Terms:

KEYWORDS: Toxicogenetics

MESH TERMS: trends

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Grant and Affiliation Information for Toxicogenomics in drug discovery and drug development: potential applications and future challenges.

AFFILIATION: Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers University, 160 Frelinghuysen Road, Piscataway, New Jersey 08854, USA.

Country: United States

AGENCY: United States NCI

GRANT: CA118947

ACRONYM: CA

MEDLINETA: Pharm Res

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