Toxic effects of lipopolysaccharide from Bacteroides intermedius and Escherichia coli assessed in the pre-implantation mouse embryo culture system.

Toxic effects of lipopolysaccharide from Bacteroides intermedius and Escherichia coli assessed in the pre-implantation mouse embryo culture system. Research Abstract Details 

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Toxic effects of lipopolysaccharide from Bacteroides intermedius and Escherichia coli assessed in the pre-implantation mouse embryo culture system. Abstract Text:

R Storeng,B Johne,

A comparative study on the toxic effects of endotoxin (lipopolysaccharide, LPS) from the strictly anaerobic Bacteroides intermedius BM1 and from Escherichia coli 055 was performed. Pre-implantation mouse embryos at the 2-cell stage from LPS responder (C57BL/6J) and low responder (C3H/Hej) mouse strains were exposed to the endotoxins, and development was observed during 72 h in vitro. Toxic effects of both endotoxins on embryos from both mouse strains were demonstrated. B. intermedius LPS was less toxic than E. coli LPS. The C3H/Hej embryos were more susceptible to endotoxins than the C57BL/6J embryos. A biphasic dose-response relationship was observed, as 100 micrograms/ml LPS was less embryotoxic than 1, 10 or 500 micrograms/ml, suggesting more complex mechanisms of effect than non-specific cell toxicity.

Toxic effects of lipopolysaccharide from Bacteroides intermedius and Escherichia coli assessed in the pre-implantation mouse embryo culture system. Publishing Authors By Initials

R Storeng,B Johne,

For similar animals: animal population groups: animals, inbred strains: mice, inbred strains: mice, inbred cba research abstracts see: animals: animal population groups: animals, inbred strains: mice, inbred strains: mice, inbred cba research

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Toxic effects of lipopolysaccharide from Bacteroides intermedius and Escherichia coli assessed in the pre-implantation mouse embryo culture system. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Acta pathologica, microbiologica, et immunologica

VOLUME: 95

Page Numbers: 135-9

Journal Abbreviation:

ISSN: 0108-0180

DAY: 12

MONTH: Apr

YEAR: 1987

Toxic effects of lipopolysaccharide from Bacteroides intermedius and Escherichia coli assessed in the pre-implantation mouse embryo culture system. Information

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LANGUAGE: eng

NlmUniqueID: 8206623

Toxic effects of lipopolysaccharide from Bacteroides intermedius and Escherichia coli assessed in the pre-implantation mouse embryo culture system. Keywords Mesh Terms:

KEYWORDS: Mice, Inbred CBA

MESH TERMS: toxicity

Chemical & Substance for Abstract: Toxic effects of lipopolysaccharide from Bacteroides intermedius and Escherichia coli assessed in the pre-implantation mouse embryo culture system. Information

Substance Name: Lipopolysaccharides

Registry Number: 0

Grant and Affiliation Information for Toxic effects of lipopolysaccharide from Bacteroides intermedius and Escherichia coli assessed in the pre-implantation mouse embryo culture system.

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Country: DENMARK

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MEDLINETA: Acta Pathol Microbiol Immunol

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