Toward understanding how the lactone moiety of discodermolide affects activity.

Toward understanding how the lactone moiety of discodermolide affects activity. Research Abstract Details 

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Toward understanding how the lactone moiety of discodermolide affects activity. Abstract Text:

Simon J Shaw,Kurt F Sundermann,Mark A Burlingame,David C Myles,B Scott Freeze,Ming Xian,Ignacio Brouard,Amos B Smith,

A series of simplified discodermolide analogues have been designed and synthesized in an attempt to understand the role of the lactone ring. These synthetic efforts have led to an unsubstituted butyrolactone 9 being generated, which shows improved activity over the natural product.

Toward understanding how the lactone moiety of discodermolide affects activity. Publishing Authors By Initials

SJ Shaw,KF Sundermann,MA Burlingame,DC Myles,BS Freeze,M Xian,I Brouard,AB Smith,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: structure-activity relationship research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: structure-activity relationship research

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Toward understanding how the lactone moiety of discodermolide affects activity. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of the American Chemical Society

VOLUME: 127

Page Numbers: 6532-3

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 11

MONTH: May

YEAR: 2005

Toward understanding how the lactone moiety of discodermolide affects activity. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7503056

Toward understanding how the lactone moiety of discodermolide affects activity. Keywords Mesh Terms:

KEYWORDS: Structure-Activity Relationship

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Toward understanding how the lactone moiety of discodermolide affects activity. Information

Substance Name: discodermolide

Registry Number: 127943-53-7

Grant and Affiliation Information for Toward understanding how the lactone moiety of discodermolide affects activity.

AFFILIATION: Kosan Biosciences, Inc., 3832 Bay Center Place, Hayward, CA 94545, USA. shaw@kosan.com

Country: United States

AGENCY: United States NIGMS

GRANT: GM 29028

ACRONYM: GM

MEDLINETA: J Am Chem Soc

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