Toward the development of chemoprevention agents (III): Synthesis and anti-inflammatory activities of a new class of 5-glycylamino-2-substituted-phenyl-1,3-dioxacycloalkanes.

Toward the development of chemoprevention agents (III): Synthesis and anti-inflammatory activities of a new class of 5-glycylamino-2-substituted-phenyl-1,3-dioxacycloalkanes. Research Abstract Details 

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Toward the development of chemoprevention agents (III): Synthesis and anti-inflammatory activities of a new class of 5-glycylamino-2-substituted-phenyl-1,3-dioxacycloalkanes. Abstract Text:

Lanrong Bi,Ming Zhao,Keli Gu,Chao Wang,Jingfang Ju,Shiqi Peng,Lanrong Bi,Ming Zhao,Keli Gu,Chao Wang,Jingfang Ju,Shiqi Peng,

A new series of 5-glycylamino-2-substituted-phenyl-1,3-dioxacycloalkanes were designed and synthesized. The anti-inflammatory activities of these compounds were tested using the xylene-induced mouse ear edema model. Sixteen of these new compounds exhibited comparable or better anti-inflammatory activities than aspirin suggesting that they can be further developed as potential anti-inflammatory drug leads. In addition, treatment with these anti-inflammatory agents did not prolong tail bleeding time in mice. The structure/activity relationships were also analyzed among these compounds. Considering their good efficacy and safety profiles, some 5-glycylamino-2-substituted-phenyl-1,3-dioxacycloalkanes are worthy to be explored further in assessing the possible link between anti-inflammation and cancer prevention.

Toward the development of chemoprevention agents (III): Synthesis and anti-inflammatory activities of a new class of 5-glycylamino-2-substituted-phenyl-1,3-dioxacycloalkanes. Publishing Authors By Initials

L Bi,M Zhao,K Gu,C Wang,J Ju,S Peng,L Bi,M Zhao,K Gu,C Wang,J Ju,S Peng,

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Toward the development of chemoprevention agents (III): Synthesis and anti-inflammatory activities of a new class of 5-glycylamino-2-substituted-phenyl-1,3-dioxacycloalkanes. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Bioorganic & medicinal chemistry

VOLUME: 16

Page Numbers: 1764-74

Journal Abbreviation: Bioorg. Med. Chem.

ISSN: 1464-3391

DAY: 12

MONTH: 11

YEAR: 2007

Toward the development of chemoprevention agents (III): Synthesis and anti-inflammatory activities of a new class of 5-glycylamino-2-substituted-phenyl-1,3-dioxacycloalkanes. Information

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LANGUAGE: eng

NlmUniqueID: 9413298

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Grant and Affiliation Information for Toward the development of chemoprevention agents (III): Synthesis and anti-inflammatory activities of a new class of 5-glycylamino-2-substituted-phenyl-1,3-dioxacycloalkanes.

AFFILIATION: College of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, PR China.

Country: England

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MEDLINETA: Bioorg Med Chem

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