Toward fully synthetic glycoproteins by ultimately convergent routes: a solution to a long-standing problem.

Toward fully synthetic glycoproteins by ultimately convergent routes: a solution to a long-standing problem. Research Abstract Details 

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Toward fully synthetic glycoproteins by ultimately convergent routes: a solution to a long-standing problem. Abstract Text:

J David Warren,Justin S Miller,Stacy J Keding,Samuel J Danishefsky,

A method is disclosed for the convergent synthesis of multiply glycosylated peptides. The approach centers on a convergent technique for generating masked, complex glycopeptide-containing C-terminal acyl donors. Activation of the latent donor in situ and use directly in segment coupling with a second peptide bearing a complex carbohydrate produces a completely unprotected, bifunctional glycopeptide. The system demonstrates a minimum level of hydrolysis and epimerization at the C-terminal amino acid residue of the acyl donor during fully convergent segment coupling and is therefore a powerful tool for the synthesis of glycoproteins.

Toward fully synthetic glycoproteins by ultimately convergent routes: a solution to a long-standing problem. Publishing Authors By Initials

JD Warren,JS Miller,SJ Keding,SJ Danishefsky,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: molecular structure: molecular conformation: protein conformation research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: molecular structure: molecular conformation: protein conformation research

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Toward fully synthetic glycoproteins by ultimately convergent routes: a solution to a long-standing problem. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of the American Chemical Society

VOLUME: 126

Page Numbers: 6576-8

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 2

MONTH: Jun

YEAR: 2004

Toward fully synthetic glycoproteins by ultimately convergent routes: a solution to a long-standing problem. Information

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LANGUAGE: eng

NlmUniqueID: 7503056

Toward fully synthetic glycoproteins by ultimately convergent routes: a solution to a long-standing problem. Keywords Mesh Terms:

KEYWORDS: Protein Conformation

MESH TERMS: chemistry

Chemical & Substance for Abstract: Toward fully synthetic glycoproteins by ultimately convergent routes: a solution to a long-standing problem. Information

Substance Name: Erythropoietin

Registry Number: 11096-26-7

Grant and Affiliation Information for Toward fully synthetic glycoproteins by ultimately convergent routes: a solution to a long-standing problem.

AFFILIATION: Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10021, USA.

Country: United States

AGENCY: United States NCI

GRANT: CA62948

ACRONYM: CA

MEDLINETA: J Am Chem Soc

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