Toward fully synthetic carbohydrate-based HIV antigen design: on the critical role of bivalency.

Toward fully synthetic carbohydrate-based HIV antigen design: on the critical role of bivalency. Research Abstract Details 

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Toward fully synthetic carbohydrate-based HIV antigen design: on the critical role of bivalency. Abstract Text:

Vadim Y Dudkin,Marianna Orlova,Xudong Geng,Mihirbaran Mandal,William C Olson,Samuel J Danishefsky,

Synthetic gp120331-335 glycopeptide fragments carrying hybrid and high-mannose type N-linked glycans were evaluated for binding to broadly neutralizing antibody 2G12 using surface plasmon resonance technology. None of the hybrid-type constructs demonstrated binding to 2G12. In the high-mannose series, the "Cys dimer" construct, presenting two undecasaccharide glycans, showed significantly higher binding than the Cys-protected monomer. The binding of the dimeric structure was further investigated in competition with recombinant gp120. The data suggest that gp120 and its designed synthetic epitope construct bind to the same site on 2G12.

Toward fully synthetic carbohydrate-based HIV antigen design: on the critical role of bivalency. Publishing Authors By Initials

VY Dudkin,M Orlova,X Geng,M Mandal,WC Olson,SJ Danishefsky,

For similar peptides: peptide fragments research abstracts see: peptides: peptide fragments research

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Toward fully synthetic carbohydrate-based HIV antigen design: on the critical role of bivalency. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of the American Chemical Society

VOLUME: 126

Page Numbers: 9560-2

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 11

MONTH: Aug

YEAR: 2004

Toward fully synthetic carbohydrate-based HIV antigen design: on the critical role of bivalency. Information

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LANGUAGE: eng

NlmUniqueID: 7503056

Toward fully synthetic carbohydrate-based HIV antigen design: on the critical role of bivalency. Keywords Mesh Terms:

KEYWORDS: Peptide Fragments

MESH TERMS: immunology

Chemical & Substance for Abstract: Toward fully synthetic carbohydrate-based HIV antigen design: on the critical role of bivalency. Information

Substance Name: Mannose

Registry Number: 31103-86-3

Grant and Affiliation Information for Toward fully synthetic carbohydrate-based HIV antigen design: on the critical role of bivalency.

AFFILIATION: Laboratory for Bioorganic Chemistry, The Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10021, USA.

Country: United States

AGENCY: United States NCI

GRANT: CA-28824

ACRONYM: CA

MEDLINETA: J Am Chem Soc

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