Toward artificial developmental regulators.

Toward artificial developmental regulators. Research Abstract Details 

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Toward artificial developmental regulators. Abstract Text:

Hans-Dieter Arndt,Karl E Hauschild,David P Sullivan,Kara Lake,Peter B Dervan,Aseem Z Ansari,

A polyamide-peptide conjugate is designed which recruits sequence specifically the developmental regulator Exd to a cognate DNA site. In particular, an eight-ring hairpin polyamide (Im-Im-Py(C3H6NHR)-Py-gamma-Im-Py-Py-Py-beta-Dp) with a heptapeptide (R = Ac-Phe-Tyr-Pro-Trp-Met-Lys-Gly-) attached on a central ring was shown to induce cooperative binding of the Drosophila Hox protein cofactor Exd with a Kd of 4.4 nM in vitro, an order of magnitude more efficient than the natural Hox protein partner Ubx. The conjugate joins two sequence specific domains, one for DNA and one for the protein. This small molecule thus serves as a cooperative protein-DNA dimerizer, which mimics the natural Hox family of developmental regulators.

Toward artificial developmental regulators. Publishing Authors By Initials

HD Arndt,KE Hauschild,DP Sullivan,K Lake,PB Dervan,AZ Ansari,

For similar proteins: transcription factors research abstracts see: proteins: transcription factors research

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Toward artificial developmental regulators. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of the American Chemical Society

VOLUME: 125

Page Numbers: 13322-3

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 5

MONTH: Nov

YEAR: 2003

Toward artificial developmental regulators. Information

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LANGUAGE: eng

NlmUniqueID: 7503056

Toward artificial developmental regulators. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: metabolism

Chemical & Substance for Abstract: Toward artificial developmental regulators. Information

Substance Name: DNA

Registry Number: 9007-49-2

Grant and Affiliation Information for Toward artificial developmental regulators.

AFFILIATION: California Institute of Technology, Division of Chemistry and Chemical Engineering, Pasadena, California 91125, USA.

Country: United States

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MEDLINETA: J Am Chem Soc

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