Total synthesis of the duocarmycins.

Total synthesis of the duocarmycins. Research Abstract Details 

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Total synthesis of the duocarmycins. Abstract Text:

Ken Yamada,Toshiki Kurokawa,Hidetoshi Tokuyama,Tohru Fukuyama,

The total synthesis of (+)-duocarmycin A and SA through a common indoline intermediate is described. The key reactions include selective lithiation of a 2,6-dibromoiodobenzene derivative and diastereoselective addition to a chiral nitroalkene, copper-mediated aryl amination, and addition of aryllithium to azlactones.

Total synthesis of the duocarmycins. Publishing Authors By Initials

K Yamada,T Kurokawa,H Tokuyama,T Fukuyama,

For similar bacteria: endospore-forming bacteria: gram-positive endospore-forming bacteria: gram-positive endospore-forming rods: streptomycetaceae: streptomyces research abstracts see: bacteria: endospore-forming bacteria: gram-positive endospore-forming bacteria: gram-positive endospore-forming rods: streptomycetaceae: streptomyces research

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Total synthesis of the duocarmycins. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of the American Chemical Society

VOLUME: 125

Page Numbers: 6630-1

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 4

MONTH: Jun

YEAR: 2003

Total synthesis of the duocarmycins. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7503056

Total synthesis of the duocarmycins. Keywords Mesh Terms:

KEYWORDS: Streptomyces

MESH TERMS: chemistry

Chemical & Substance for Abstract: Total synthesis of the duocarmycins. Information

Substance Name: duocarmycin SA

Registry Number: 130288-24-3

Grant and Affiliation Information for Total synthesis of the duocarmycins.

AFFILIATION: Graduate School of Pharmaceutical Sciences, University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.

Country: United States

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MEDLINETA: J Am Chem Soc

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