Total synthesis of salinosporamide A.

Total synthesis of salinosporamide A. Research Abstract Details 

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Total synthesis of salinosporamide A. Abstract Text:

Atsushi Endo,Samuel J Danishefsky,

Total synthesis of potent proteasome inhibitor salinosporamide A (1) has been accomplished, which features strictly substrate-controlled operations starting with the only chiral center of (R)-pyroglutamic acid. The consecutive quaternary carbons within 1 have been efficiently constructed by manipulation of two intramolecular reactions: (1) carbonate-mediated internal acylation of imidate ester (4 --> 14) and (2) selenocyclization of aldehyde to exocyclic methylene group (5 --> 18).

Total synthesis of salinosporamide A. Publishing Authors By Initials

A Endo,SJ Danishefsky,

For similar natural sciences: chemistry: chemistry, organic: isomerism: stereoisomerism research abstracts see: natural sciences: chemistry: chemistry, organic: isomerism: stereoisomerism research

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Total synthesis of salinosporamide A. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of the American Chemical Society

VOLUME: 127

Page Numbers: 8298-9

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 15

MONTH: Jun

YEAR: 2005

Total synthesis of salinosporamide A. Information

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LANGUAGE: eng

NlmUniqueID: 7503056

Total synthesis of salinosporamide A. Keywords Mesh Terms:

KEYWORDS: Stereoisomerism

MESH TERMS: chemistry

Chemical & Substance for Abstract: Total synthesis of salinosporamide A. Information

Substance Name: Selenium

Registry Number: 7782-49-2

Grant and Affiliation Information for Total synthesis of salinosporamide A.

AFFILIATION: Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10021, USA.

Country: United States

AGENCY: United States NCI

GRANT: CA 28824

ACRONYM: CA

MEDLINETA: J Am Chem Soc

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