Total synthesis of reblastatin.

Total synthesis of reblastatin. Research Abstract Details 

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Total synthesis of reblastatin. Abstract Text:

Iwona E Wrona,Ana E Gabarda,Gwilherm Evano,James S Panek,

Enantioselective total synthesis of reblastatin is described. The synthesis highlights hydrozirconation, transmetalation, aldehyde addition sequence to install E-trisubstituted olefin and C7 stereocenter, and the first use of an intramolecular Buchwald-like amidation reaction to close the 19-membered macrolactam.

Total synthesis of reblastatin. Publishing Authors By Initials

IE Wrona,AE Gabarda,G Evano,JS Panek,

For similar organic chemicals: quinones research abstracts see: organic chemicals: quinones research

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Total synthesis of reblastatin. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of the American Chemical Society

VOLUME: 127

Page Numbers: 15026-7

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 2

MONTH: Nov

YEAR: 2005

Total synthesis of reblastatin. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7503056

Total synthesis of reblastatin. Keywords Mesh Terms:

KEYWORDS: Quinones

MESH TERMS: chemical synthesis

Chemical & Substance for Abstract: Total synthesis of reblastatin. Information

Substance Name: reblastatin

Registry Number: 0

Grant and Affiliation Information for Total synthesis of reblastatin.

AFFILIATION: Department of Chemistry, Boston University, Boston, Massachusetts 02215, USA.

Country: United States

AGENCY: United States NCI

GRANT: CA56304

ACRONYM: CA

MEDLINETA: J Am Chem Soc

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