Total synthesis of N14-desacetoxytubulysin H.

Total synthesis of N14-desacetoxytubulysin H. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Total synthesis of N14-desacetoxytubulysin H. Abstract Text:

Peter Wipf,Zhiyong Wang,

[reaction: see text] The N14-desacetoxy analogue of tubulysin H was prepared in 20 steps and 2.1% overall yield. Our strategy features a thiazole anion addition to assemble the tubuvaline residue at the C(10)-C(11) bond, as well as acylations at N5, N14, and N17. This iterative coupling approach, as well as the removal of the labile N,O-acetal at N14, enables the synthesis of analogues for detailed studies of structure-activity relationships in this family of potent tubulin disrupters.

Total synthesis of N14-desacetoxytubulysin H. Publishing Authors By Initials

P Wipf,Z Wang,

For similar organic chemicals research abstracts see: organic chemicals research

PUBMED ID PMID:

MEDLINE DATE:

Total synthesis of N14-desacetoxytubulysin H. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Organic letters

VOLUME: 9

Page Numbers: 1605-7

Journal Abbreviation:

ISSN: 1523-7060

DAY: 17

MONTH: 03

YEAR: 2007

Total synthesis of N14-desacetoxytubulysin H. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100890393

Total synthesis of N14-desacetoxytubulysin H. Keywords Mesh Terms:

KEYWORDS: Organic Chemicals

MESH TERMS: chemistry

Chemical & Substance for Abstract: Total synthesis of N14-desacetoxytubulysin H. Information

Substance Name: Organic Chemicals

Registry Number: 0

Grant and Affiliation Information for Total synthesis of N14-desacetoxytubulysin H.

AFFILIATION: Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA. pwipf+@pitt.edu

Country: United States

AGENCY: United States NCI

GRANT: CA78039

ACRONYM: CA

MEDLINETA: Org Lett

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Total synthesis of N14-desacetoxytubulysin H Related Publications

• A novel link between the proteasome pathway and the signal transduction pathway of the bone morphogenetic proteins (BMPs).
• Effects of phytoestrogen genistein on delayed after depolarization and triggered activity induced by ouabain in guinea pig papillary muscles.
• Occupational health in China.
• Research on expression of telomerase in human odontogenic lesions.
• Suppression of tumor necrosis factor-mediated apoptosis by nuclear factor kappaB-independent bone morphogenetic protein/Smad signaling.
• [A gene analysis of the low density lipoprotein receptor in Chinese with homozygous familial hyperchol-esterolemia]
• [A novel rat aplastic anemia model induced by 5-fluorouracil combined with busulfan]
• [A study of association between atherothrombotic brain infarction and HLA-DQA1 peptide binding motifs]
• [An experimental study on the bone repairing ability of recombinant human bone morphogenetic protein-2-coral composited artificial bone]
• [Analysis of EEG based on the complexity measure]
• [Apoptosis of bone marrow cells aplastic anemia patients treated with cyclosporin A]
• [Carrier detection and prenatal diagnosis for hemophilia A]
• [Changes of the expression of integrin alpha6beta1 and the activity of focal adhesion kinase in the liver sinusoidal endothelial cell in experimental fibrotic rats]
• [Clinical analysis of 22 patients with primary biliary cirrhosis]
• [Clinical significance of hemostatic molecular markers in acute leukemia]
• [Effects of phenytoin on structural aberration of human sperm chromosomes in vitro]
• [Expression and purification of human papillomavirus type16 L1 protein in a prokaryotic expression system]
• [Extension of cardiac monitoring function by used of ordinary ECG machine]
• [Histopathological features of 27 cases of primary biliary cirrhosis]
• [Multiagent system for individual artificial hip joint]
• [Neomycin inhibits nicotinic receptor-mediated response in pheochromocytoma (PC12) cells]
• [No evidence for association between the alpha 2-macroglobulin polymorphism and Alzheimer's disease in the Han Chinese]
• [PCR cloning of 3'-terminal repeat fragments of Clostridium difficile toxin A and toxin B gene]
• [Preliminary study of prevention from restenosis of hepatic venous in stents by gene transfer of phVEGF165]
• [Prostaglandin inhibitor indomethacin inhibits afferent activities of Adelta and C units in the saphenous nerve of diabetic hyperalgesic rats]
• [Research and development on microwave sterilization]
• [Role of recombinant human bone morphogenetic protein 2/collagen as an onlay bone graft on adult rat calvarial bone]
• [Study of telomerase activity and its related genes expression in leukemia cells]
• [Thrombopoietic effect of recombinant human thrombopoietin gene transferred to mice mediated by electric pulse on normal and experimental thrombocytopenia mice]
• [Thymectomy for late-onset myasthenia gravis in the elderly (with report of 23 cases)]