The convergent total synthesis of gambierol (1) is described. The octacyclic ether framework of 1 was constructed via the intramolecular allylation of alpha-chloroacetoxy ether followed by ring-closing metathesis. A modified Stille coupling was successfully applied to the synthesis of the triene side chain.
Total synthesis of gambierol. Publishing Authors By Initials
Total synthesis of gambierol. Keywords Mesh Terms:
KEYWORDS: Polycyclic Compounds
MESH TERMS: chemical synthesis
Chemical & Substance for Abstract: Total synthesis of gambierol. Information
Substance Name: Ciguatoxins
Registry Number: 11050-21-8
Grant and Affiliation Information for Total synthesis of gambierol.
AFFILIATION: Research Center for Sustainable Materials Engineering, Institute of Multidisciplinary Research for Advanced Materials, and Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan.