Total synthesis of (+/-)-jiadifenin, a non-peptidyl neurotrophic modulator.

Total synthesis of (+/-)-jiadifenin, a non-peptidyl neurotrophic modulator. Research Abstract Details 

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Total synthesis of (+/-)-jiadifenin, a non-peptidyl neurotrophic modulator. Abstract Text:

Young Shin Cho,David A Carcache,Yuan Tian,Yue-Ming Li,Samuel J Danishefsky,

We report the first total synthesis of jiadifenin (1), the establishment of a modality for its biological evaluation, and the discovery of apparently more potent neurotrophic activity in fully synthetic compound 17, an intermediate en route to 1.

Total synthesis of (+/-)-jiadifenin, a non-peptidyl neurotrophic modulator. Publishing Authors By Initials

YS Cho,DA Carcache,Y Tian,YM Li,SJ Danishefsky,

For similar organic chemicals: hydrocarbons: terpenes: sesquiterpenes research abstracts see: organic chemicals: hydrocarbons: terpenes: sesquiterpenes research

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Total synthesis of (+/-)-jiadifenin, a non-peptidyl neurotrophic modulator. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of the American Chemical Society

VOLUME: 126

Page Numbers: 14358-9

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 10

MONTH: Nov

YEAR: 2004

Total synthesis of (+/-)-jiadifenin, a non-peptidyl neurotrophic modulator. Information

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LANGUAGE: eng

NlmUniqueID: 7503056

Total synthesis of (+/-)-jiadifenin, a non-peptidyl neurotrophic modulator. Keywords Mesh Terms:

KEYWORDS: Sesquiterpenes

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Total synthesis of (+/-)-jiadifenin, a non-peptidyl neurotrophic modulator. Information

Substance Name: jiadifenin

Registry Number: 0

Grant and Affiliation Information for Total synthesis of (+/-)-jiadifenin, a non-peptidyl neurotrophic modulator.

AFFILIATION: Laboratory for Bioorganic Chemistry and Laboratory of Biochemistry and Pharmacology, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10021, USA.

Country: United States

AGENCY: United States NCI

GRANT: CA-103823-25

ACRONYM: CA

MEDLINETA: J Am Chem Soc

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