Total synthesis and absolute configuration of laurenditerpenol: a hypoxia inducible factor-1 activation inhibitor.

Total synthesis and absolute configuration of laurenditerpenol: a hypoxia inducible factor-1 activation inhibitor. Research Abstract Details 

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Total synthesis and absolute configuration of laurenditerpenol: a hypoxia inducible factor-1 activation inhibitor. Abstract Text:

Amar G Chittiboyina,Gundluru Mahesh Kumar,Paulo B Carvalho,Yang Liu,Yu-Dong Zhou,Dale G Nagle,Mitchell A Avery,Amar G Chittiboyina,Gundluru Mahesh Kumar,Paulo B Carvalho,Yang Liu,Yu-Dong Zhou,Dale G Nagle,Mitchell A Avery,

The absolute stereo structure of the natural product laurenditerpenol (1S, 6R, 7S, 10R, 11R, 14S, 15R) has been accomplished from eight plausible stereoisomers by its first asymmetric total synthesis in a highly convergent and flexible synthetic pathway. Six stereoisomers of laurenditerpenol were synthesized and evaluated for their biological activity.

Total synthesis and absolute configuration of laurenditerpenol: a hypoxia inducible factor-1 activation inhibitor. Publishing Authors By Initials

AG Chittiboyina,GM Kumar,PB Carvalho,Y Liu,YD Zhou,DG Nagle,MA Avery,AG Chittiboyina,GM Kumar,PB Carvalho,Y Liu,YD Zhou,DG Nagle,MA Avery,

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Total synthesis and absolute configuration of laurenditerpenol: a hypoxia inducible factor-1 activation inhibitor. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of medicinal chemistry

VOLUME: 50

Page Numbers: 6299-302

Journal Abbreviation: J. Med. Chem.

ISSN: 0022-2623

DAY: 16

MONTH: 11

YEAR: 2007

Total synthesis and absolute configuration of laurenditerpenol: a hypoxia inducible factor-1 activation inhibitor. Information

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LANGUAGE: eng

NlmUniqueID: 9716531

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Grant and Affiliation Information for Total synthesis and absolute configuration of laurenditerpenol: a hypoxia inducible factor-1 activation inhibitor.

AFFILIATION: University of Mississippi. University, Mississippi 38677-1848, USA.

Country: United States

AGENCY: United States NCI

GRANT: NIH-NCI CA98787

ACRONYM: CA

MEDLINETA: J Med Chem

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