Total solid-phase synthesis of bombesin analogs with different functional groups at the C-terminus.

Total solid-phase synthesis of bombesin analogs with different functional groups at the C-terminus. Research Abstract Details 

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Total solid-phase synthesis of bombesin analogs with different functional groups at the C-terminus. Abstract Text:

Wael R Abd-Elgaliel,Fabio Gallazzi,Susan Z Lever,

Five bombesin analogs with different functional groups at the C-terminus were synthesized using a solid-phase strategy. The protocols were optimized using 4-(hydroxymethyl)benzoic acid (HMBA) resin to synthesize a common precursor followed by nucleophilic cleavage of the base sensitive peptide ester linkage. The C-terminal modifications included ethylamide, butylamide, methyl ester, propyl ester and hydrazide. Cleavage from the resin was possible with the fully protected or deprotected precursor peptide; however, higher purity of the final products was achieved when cleavage protocols were conducted after side-chain deprotection. The synthesized peptides were analyzed and characterized using reverse phase HPLC and ESI-MS. The peptides were obtained in 13-32% overall recovery, calculated from the coupling efficiency of the first amino acid residue, and in 91-97% purity.

Total solid-phase synthesis of bombesin analogs with different functional groups at the C-terminus. Publishing Authors By Initials

WR Abd-Elgaliel,F Gallazzi,SZ Lever,

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Total solid-phase synthesis of bombesin analogs with different functional groups at the C-terminus. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of peptide science : an official publicati

VOLUME: 13

Page Numbers: 487-92

Journal Abbreviation: J. Pept. Sci.

ISSN: 1075-2617

DAY: 3

MONTH: Jul

YEAR: 2007

Total solid-phase synthesis of bombesin analogs with different functional groups at the C-terminus. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9506309

Total solid-phase synthesis of bombesin analogs with different functional groups at the C-terminus. Keywords Mesh Terms:

KEYWORDS: Spectrometry, Mass, Electrospray Ionizat

MESH TERMS: chemistry

Chemical & Substance for Abstract: Total solid-phase synthesis of bombesin analogs with different functional groups at the C-terminus. Information

Substance Name: Bombesin

Registry Number: 31362-50-2

Grant and Affiliation Information for Total solid-phase synthesis of bombesin analogs with different functional groups at the C-terminus.

AFFILIATION: Department of Chemistry, University of Missouri-Columbia, Columbia, Missouri 65211, USA.

Country: England

AGENCY: United States NCI

GRANT: P50 CA103130

ACRONYM: CA

MEDLINETA: J Pept Sci

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