Total parenteral nutrition-related liver disease.

Total parenteral nutrition-related liver disease. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Total parenteral nutrition-related liver disease. Abstract Text:

R J Sokol,

Administration of parenteral nutrition to the small infant has decreased morbidity but is associated with the development of cholestasis and liver dysfunction in a high proportion of infants. In this review, contributing factors of the etiopathogenesis of parenteral nutrition-associated liver disease will be outlined, forming the basis for a unifying theory of its pathogenesis. It is proposed that oxidant stress and stimulation of hepatic Kupffer cells by bacterial cell wall products absorbed from the injured intestine are major factors leading to cholestasis and liver injury during prolonged parenteral nutrition. Improved outcome in patients has been related to the early introduction of feedings. New proposed therapeutic modalities have included antibiotics and probiotics to prevent bacterial overgrowth of the small intestine, enterally-administered ursodeoxycholic acid and intravenous cholecystokinin. Improved understanding of the fundamental mechanisms producing liver injury and fibrosis during parenteral nutrition will lead to new preventative and treatment measures in the future.

Total parenteral nutrition-related liver disease. Publishing Authors By Initials

RJ Sokol,

For similar therapeutics: feeding methods: parenteral nutrition: parenteral nutrition, total research abstracts see: therapeutics: feeding methods: parenteral nutrition: parenteral nutrition, total research

PUBMED ID PMID:

MEDLINE DATE:

Total parenteral nutrition-related liver disease. Journal Published:

PUBLICATION TYPE: Review

Journal: Zhonghua Minguo xiao er ke yi xue hui za zhi [Jour

VOLUME: 38

Page Numbers: 418-28

Journal Abbreviation:

ISSN: 0001-6578

DAY: 12

MONTH: 02

YEAR: 2008

Total parenteral nutrition-related liver disease. Information

Number of References: 50

LANGUAGE: eng

NlmUniqueID: 16210470

Total parenteral nutrition-related liver disease. Keywords Mesh Terms:

KEYWORDS: Parenteral Nutrition, Total

MESH TERMS: adverse effects

Chemical & Substance for Abstract: Total parenteral nutrition-related liver disease. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Total parenteral nutrition-related liver disease.

AFFILIATION: Pediatric Liver Center, University of Colorado School of Medicine, Denver 80218-1088, USA. sokol.ronald@tchden.org

Country: TAIWAN

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Zhonghua Min Guo Xiao Er Ke Yi

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Total parenteral nutrition-related liver disease Related Publications

• A LysR-type transcriptional regulator in Burkholderia cenocepacia influences colony morphology and virulence.
• A perforated education.
• Aggressive T-cell large granular lymphocyte leukemia: a case report and review of the literature.
• Dialkylaminoalkyl esters and amides derived from 3-hydroxy-and 3-alkoxy-2-naphthoic acids.
• Dialkylaminoethyl esters of 4-nitro- and 4-amino-3-hydroxy-2-naphthoic acids.
• Duodenal stump tumor.
• Growth failure and outcomes in infants with biliary atresia: a report from the Biliary Atresia Research Consortium.
• How far would you go?
• Lingual epilepsia partialis continua in a girl.
• Liver disease in mitochondrial disorders.
• Long-term follow-up of a transvaginal Burch urethropexy for stress urinary incontinence.
• Mitochondrial hepatopathies: advances in genetics and pathogenesis.
• PAR1 specifies ciliated cells in vertebrate ectoderm downstream of aPKC.
• Purification of rabies virus and isolation of its components.
• Shoulder dystocia and the next delivery: outcomes and management.
• Skeletal muscle peripheral T-cell lymphoma.
• Subcutaneous vitamin E ameliorates liver injury in an in vivo model of steatocholestasis.
• The allocation of scarce medical resources: a philosophical analysis of the halakhic sources.
• The dilemma of authorship.
• The effects of copayments on medication adherence during the first two years of prescription drug treatment.
• The ethical junior: a typology of ethical problems faced by house officers.
• The role of maternal acceptance in the relation between community violence exposure and child functioning.
• Total parenteral nutrition-related liver disease.
• Widespread epigenetic abnormalities suggest a broad DNA methylation erasure defect in abnormal human sperm.
• William Osler and the jubjub of ethics; or how to teach medical ethics in the 21st century.
• [Bioelectric uterograms.]
• [Features of ontogenesis of uroliths]
• [Perinatal asphyxia and psychopathologic symptomatology in adolescence]
• [The management of uterine motility during labor]
• [Vaginotonography and vaginotonometry; description of a new aid in vaginal and pelvic muscle training.]