Topographic brain mapping of the international cooperative ataxia rating scale. A positron emission tomography study.

Topographic brain mapping of the international cooperative ataxia rating scale. A positron emission tomography study. Research Abstract Details 

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Topographic brain mapping of the international cooperative ataxia rating scale. A positron emission tomography study. Abstract Text:

Po-Shan Wang,Ren-Shyan Liu,Bang-Hung Yang,Bing-Wen Soong,Po-Shan Wang,Ren-Shyan Liu,Bang-Hung Yang,Bing-Wen Soong,

The International Cooperative Ataxia Rating Scale (ICARS) is a 100-point semiquantitative scale designed primarily to assess cerebellar dysfunction. However, little is known of the metric properties of this scale. We assessed the ICARS by rating the severity of cerebellar dysfunction in 27 patients with spinocerebellar ataxias (SCA), three patients with sporadic olivopontocerebellar ataxia and 24 healthy control subjects. [(18)F]-fluorodeoxyglucose (FDG) positron emission tomography (PET) study was also performed on each subject. The statistical parametric mapping analyses revealed a significant correlation between the ICARS scores and functional impairment of the frontal regions within SCA patients. The glucose metabolism in the cerebellum, thalamus and caudate nucleus had significant differences between SCA patients and healthy control subjects. The results suggested that the clinical severity of SCA patients correlated with the functional impairment in the frontal regions, the targets of cerebellar efferent projections.

Topographic brain mapping of the international cooperative ataxia rating scale. A positron emission tomography study. Publishing Authors By Initials

PS Wang,RS Liu,BH Yang,BW Soong,PS Wang,RS Liu,BH Yang,BW Soong,

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Topographic brain mapping of the international cooperative ataxia rating scale. A positron emission tomography study. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of neurology

VOLUME: 254

Page Numbers: 722-8

Journal Abbreviation: J. Neurol.

ISSN: 0340-5354

DAY: 21

MONTH: 04

YEAR: 2007

Topographic brain mapping of the international cooperative ataxia rating scale. A positron emission tomography study. Information

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LANGUAGE: eng

NlmUniqueID: 423161

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Grant and Affiliation Information for Topographic brain mapping of the international cooperative ataxia rating scale. A positron emission tomography study.

AFFILIATION: The Neurological Institute, Taipei Veterans General Hospital, #201, Sec.2, Shipai Road, Taipei, Taiwan 11217.

Country: Germany

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MEDLINETA: J Neurol

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