Topically applied nitric oxide induces T-lymphocyte infiltration in human skin, but minimal inflammation.

Topically applied nitric oxide induces T-lymphocyte infiltration in human skin, but minimal inflammation. Research Abstract Details 

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Topically applied nitric oxide induces T-lymphocyte infiltration in human skin, but minimal inflammation. Abstract Text:

Megan Mowbray,Xuejing Tan,Paul S Wheatley,Russell E Morris,Richard B Weller,Megan Mowbray,Xuejing Tan,Paul S Wheatley,Russell E Morris,Richard B Weller,Megan Mowbray,Xuejing Tan,Paul S Wheatley,Russell E Morris,Richard B Weller,Megan Mowbray,Xuejing Tan,Paul S Wheatley,Russell E Morris,Richard B Weller,

Nitric oxide (NO) plays an important role in the cutaneous response to UV radiation and in cutaneous inflammation. The presence of inducible NO synthase protein in a number of inflammatory dermatoses, coupled with the induction of an intense cutaneous inflammatory infiltrate following topical application of the NO donor-acidified nitrite (NO(2)(-)), has set the paradigm of NO being an inflammatory mediator in human skin. Using zeolite NO (Ze-NO), a chemically inert, pure NO donor, we have shown that NO per se produces little inflammation. Biologically, relevant doses of Ze-NO induce a dermal CD4-positive T-cell infiltrate and IFN-gamma secretion. In contrast acidified nitrite, releasing equal quantities of NO (measured by dermal microdialysis and cutaneous erythema), induces an intense epidermal infiltrate of macrophages with a similar dermal infiltrate of CD3-, CD4-, CD8-, and CD68-positive cells and neutrophils. Suction blisters were created in Ze-NO-treated and control skin. IFN-gamma, but not IL-4, was detected in Ze-NO-treated skin (mean control 0.1+/-0.07 pg mg(-1) protein, mean IFN-gamma 0.6+/-0.4 pg mg(-1) protein). We suggest that the potent inflammation induced by acidified NO(2)(-) is secondary to the release of additional mediators.Journal of Investigative Dermatology (2008) 128, 352-360; doi:10.1038/sj.jid.5701096; published online 4 October 2007.

Topically applied nitric oxide induces T-lymphocyte infiltration in human skin, but minimal inflammation. Publishing Authors By Initials

M Mowbray,X Tan,PS Wheatley,RE Morris,RB Weller,M Mowbray,X Tan,PS Wheatley,RE Morris,RB Weller,M Mowbray,X Tan,PS Wheatley,RE Morris,RB Weller,M Mowbray,X Tan,PS Wheatley,RE Morris,RB Weller,

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Topically applied nitric oxide induces T-lymphocyte infiltration in human skin, but minimal inflammation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of investigative dermatology

VOLUME: 128

Page Numbers: 352-60

Journal Abbreviation: J. Invest. Dermatol.

ISSN: 1523-1747

DAY: 4

MONTH: 10

YEAR: 2007

Topically applied nitric oxide induces T-lymphocyte infiltration in human skin, but minimal inflammation. Information

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LANGUAGE: eng

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AFFILIATION: 1Department of Dermatology, University of Edinburgh, Edinburgh, UK.

Country: United States

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MEDLINETA: J Invest Dermatol

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