Topical mupirocin treatment of impetigo is equal to oral erythromycin therapy.

Topical mupirocin treatment of impetigo is equal to oral erythromycin therapy. Research Abstract Details 

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Topical mupirocin treatment of impetigo is equal to oral erythromycin therapy. Abstract Text:

Topical antimicrobial therapy has not been effective in the past against cutaneous bacterial infections. In this study, a new topical antibiotic ointment, mupirocin, was compared with oral erythromycin ethylsuccinate in the treatment of impetigo. Seventy-five patients clinically diagnosed as having impetigo and with positive cultures of Staphylococcus aureus, Streptococcus pyogenes, or both were examined in an investigator-blinded study. Patients used topical mupirocin applied three times daily or the usual oral dose of erythromycin ethylsuccinate (30 to 50 mg/kg per day). Patients' lesions were examined clinically and cultured bacteriologically on days 0, 3, and 8, and 1 week after treatment. Susceptibility testing was performed on pathogens isolated to determine antibiotic resistance. Mupirocin treatment produced similar clinical results to oral erythromycin and was superior in the eradication of S aureus, including antibiotic-resistant S aureus. These results show topical mupirocin to be a safe and effective alternative to oral antibiotic therapy in the treatment of impetigo.

Topical mupirocin treatment of impetigo is equal to oral erythromycin therapy. Publishing Authors By Initials

For similar bacteria: gram-positive bacteria: gram-positive cocci: streptococcaceae: streptococcus: streptococcus pyogenes research abstracts see: bacteria: gram-positive bacteria: gram-positive cocci: streptococcaceae: streptococcus: streptococcus pyogenes research

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Topical mupirocin treatment of impetigo is equal to oral erythromycin therapy. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Archives of dermatology

VOLUME: 125

Page Numbers: 1069-73

Journal Abbreviation: Arch Dermatol

ISSN: 0003-987X

DAY: 17

MONTH: Aug

YEAR: 1989

Topical mupirocin treatment of impetigo is equal to oral erythromycin therapy. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372433

Topical mupirocin treatment of impetigo is equal to oral erythromycin therapy. Keywords Mesh Terms:

KEYWORDS: Streptococcus pyogenes

MESH TERMS: isolation & purification

Chemical & Substance for Abstract: Topical mupirocin treatment of impetigo is equal to oral erythromycin therapy. Information

Substance Name: Mupirocin

Registry Number: 12650-69-0

Grant and Affiliation Information for Topical mupirocin treatment of impetigo is equal to oral erythromycin therapy.

AFFILIATION: Department of Dermatology and Cutaneous Surgery, University of Miami, School of Medicine, FL 33101.

Country: UNITED STATES

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MEDLINETA: Arch Dermatol

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