Topical application of a novel, hydrophilic gamma-tocopherol derivative reduces photo-inflammation in mice skin.

Topical application of a novel, hydrophilic gamma-tocopherol derivative reduces photo-inflammation in mice skin. Research Abstract Details 

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Topical application of a novel, hydrophilic gamma-tocopherol derivative reduces photo-inflammation in mice skin. Abstract Text:

We previously demonstrated that a novel hydrophilic gamma-tocopherol (gamma-Toc) derivative, gamma-tocopherol-N,N-dimethylglycinate hydrochloride (gamma-TDMG) converts to gamma-Toc in the mouse skin and has a higher bioavailability than gamma-Toc itself. In the present study, we determined whether gamma-TDMG could reduce photo-inflammation in mouse skin, and compared its effectiveness to that of alpha-Toc acetate (alpha-TA). Topical pre- or post-application of 5% gamma-TDMG significantly reduced the formation of edema and tempered the increase in cyclooxygenase-2 (COX-2)-catalyzed synthesis of prostaglandin E2 (PGE2) that were induced by a single dose of UV irradiation of 2 kJ/m2 (290-380 nm, maximum 312 nm). The pre-treatment of mouse skin with 10% alpha-TA had the same anti-inflammatory effect as did gamma-TDMG. In spite of same having the ability to reduce PGE2 levels, the effect of gamma-TDMG pre-treatment on the inhibition of COX-2 mRNA/protein expression was less than that seen with 10% alpha-TA. In contrast, the increase in COX-2 activity seen after UV exposure was reduced more by gamma-TDMG than by alpha-TA, suggesting that the reduction in PGE2 levels might have been due to the direct inhibition of COX-2 activity by gamma-TDMG-derived gamma-Toc. Both Toc derivatives strongly suppressed inducible nitric oxide synthase (iNOS) mRNA expression and nitric oxide (NO) production, both of which play important roles in UV-induced inflammation. Both derivatives also significantly reduced lipid peroxidation in response to UV exposure, though gamma-TDMG's ability in this regard was less than that seen with alpha-TA, which correlated with their abilities to suppress COX-2 expression. Thus, the gamma-TDMG-derived gamma-Toc acts as an antioxidant, suppresses iNOS expression and directly inhibits COX-2 activity, all of which likely play a role in mediating its suppressive effects on photo-inflammation. Our data further suggest that the topical application of gamma-TDMG, a novel hydrophilic gamma-Toc derivative, may be efficacious in preventing and reducing UV-induced inflammation in humans.

Topical application of a novel, hydrophilic gamma-tocopherol derivative reduces photo-inflammation in mice skin. Publishing Authors By Initials

For similar heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e: tocopherols: gamma-tocopherol research abstracts see: heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e: tocopherols: gamma-tocopherol research

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Topical application of a novel, hydrophilic gamma-tocopherol derivative reduces photo-inflammation in mice skin. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of investigative dermatology

VOLUME: 126

Page Numbers: 1633-40

Journal Abbreviation: J. Invest. Dermatol.

ISSN: 0022-202X

DAY: 16

MONTH: 03

YEAR: 2006

Topical application of a novel, hydrophilic gamma-tocopherol derivative reduces photo-inflammation in mice skin. Information

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LANGUAGE: eng

NlmUniqueID: 426720

Topical application of a novel, hydrophilic gamma-tocopherol derivative reduces photo-inflammation in mice skin. Keywords Mesh Terms:

KEYWORDS: gamma-Tocopherol

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Topical application of a novel, hydrophilic gamma-tocopherol derivative reduces photo-inflammation in mice skin. Information

Substance Name: Cyclooxygenase 2

Registry Number: EC 1.14.99.1

Grant and Affiliation Information for Topical application of a novel, hydrophilic gamma-tocopherol derivative reduces photo-inflammation in mice skin.

AFFILIATION: Department of Molecular Physiology, Kyoritsu University of Pharmacy, Tokyo, Japan.

Country: United States

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MEDLINETA: J Invest Dermatol

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