Topical application of a novel ceramide derivative, K6PC-9, inhibits dust mite extract-induced atopic dermatitis-like skin lesions in NC/Nga mice.

Topical application of a novel ceramide derivative, K6PC-9, inhibits dust mite extract-induced atopic dermatitis-like skin lesions in NC/Nga mice. Research Abstract Details 

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Topical application of a novel ceramide derivative, K6PC-9, inhibits dust mite extract-induced atopic dermatitis-like skin lesions in NC/Nga mice. Abstract Text:

Jong Soon Kang,Jong-Kyung Youm,Se Kyoo Jeong,Byeong Deog Park,Won Kee Yoon,Mi Hwa Han,Hyunju Lee,Sang-Bae Han,Kiho Lee,Song-Kyu Park,Seung Hun Lee,Kyu-Hwan Yang,Eun-Yi Moon,Hwan Mook Kim,Jong Soon Kang,Jong-Kyung Youm,Se Kyoo Jeong,Byeong Deog Park,Won Kee Yoon,Mi Hwa Han,Hyunju Lee,Sang-Bae Han,Kiho Lee,Song-Kyu Park,Seung Hun Lee,Kyu-Hwan Yang,Eun-Yi Moon,Hwan Mook Kim,Jong Soon Kang,Jong-Kyung Youm,Se Kyoo Jeong,Byeong Deog Park,Won Kee Yoon,Mi Hwa Han,Hyunju Lee,Sang-Bae Han,Kiho Lee,Song-Kyu Park,Seung Hun Lee,Kyu-Hwan Yang,Eun-Yi Moon,Hwan Mook Kim,

Atopic dermatitis (AD) is a chronic inflammatory skin disease. K6PC-9 (N-Ethanol-2-hexyl-3-oxo-decanamide) is a novel synthetic ceramide derivative of PC-9S (N-Ethanol-2-mirystyl-3-oxo-stearamide), which was known to be effective in atopic and psoriatic patients. To investigate the immunomodulatory activity of K6PC-9, we examined the effect of K6PC-9 on T lymphocyte and macrophage function and the effect of topical application of K6PC-9 on skin inflammation and AD-like skin lesions in mouse models. K6PC-9 had no effect on concanavalin A-induced proliferation, interleukin (IL)-2 secretion and IL-4 secretion in mouse splenocytes. In contrast, lipopolysaccharide-induced nitrite generation was potently suppressed by K6PC-9 in mouse peritoneal macrophages. In mouse model of skin inflammation, K6PC-9 inhibited phorbol ester-induced increase in ear thickness and expression of tumor necrosis factor-alpha in the ear of BALB/c mice. Topical application of K6PC-9 also suppressed mite extract-induced AD-like skin lesions in NC/Nga mice. Increase in ear thickness was significantly inhibited by K6PC-9 in this model. K6PC-9 also blocked the infiltration of mast cells and neutrophils into the ear. Further study demonstrated that the mRNA expression of tumor necrosis factor-alpha and adhesion molecules, such as vascular cell adhesion molecule-1, intercellular adhesion molecule-1, E-selectin, was also suppressed by K6PC-9 in the ear of mite extract-treated NC/Nga mice. Taken together, the results presented in this report show that K6PC-9 has an anti-inflammatory potential and exerts beneficial effects in an animal model of AD, indicating that K6PC-9 might be used as a topical agent for the treatment of AD.

Topical application of a novel ceramide derivative, K6PC-9, inhibits dust mite extract-induced atopic dermatitis-like skin lesions in NC/Nga mice. Publishing Authors By Initials

JS Kang,JK Youm,SK Jeong,BD Park,WK Yoon,MH Han,H Lee,SB Han,K Lee,SK Park,SH Lee,KH Yang,EY Moon,HM Kim,JS Kang,JK Youm,SK Jeong,BD Park,WK Yoon,MH Han,H Lee,SB Han,K Lee,SK Park,SH Lee,KH Yang,EY Moon,HM Kim,JS Kang,JK Youm,SK Jeong,BD Park,WK Yoon,MH Han,H Lee,SB Han,K Lee,SK Park,SH Lee,KH Yang,EY Moon,HM Kim,

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Topical application of a novel ceramide derivative, K6PC-9, inhibits dust mite extract-induced atopic dermatitis-like skin lesions in NC/Nga mice. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International immunopharmacology

VOLUME: 7

Page Numbers: 1589-97

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ISSN: 1567-5769

DAY: 4

MONTH: 09

YEAR: 2007

Topical application of a novel ceramide derivative, K6PC-9, inhibits dust mite extract-induced atopic dermatitis-like skin lesions in NC/Nga mice. Information

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LANGUAGE: eng

NlmUniqueID: 100965259

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AFFILIATION: Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Cheongwon, Chungbuk, Republic of Korea.

Country: Netherlands

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MEDLINETA: Int Immunopharmacol

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