Tonic control of arterial pressure and regional hemodynamics by supra-medullary sites.

Tonic control of arterial pressure and regional hemodynamics by supra-medullary sites. Research Abstract Details 

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Tonic control of arterial pressure and regional hemodynamics by supra-medullary sites. Abstract Text:

B F Cox,M J Brody,

We examined the role of pontine sites in the tonic control of vasomotor tone under normal and reduced tidal volumes. Lidocaine was microinjected in pons at the level of the Kölliker-Fuse nucleus (KFN). Injections were made bilaterally 6, 7, 8, and 9 mm below dura, and 0.9 and 2.5 mm lateral to midline. Lidocaine in KFN produced a fall (-14 mmHg) in mean arterial pressure (MAP) at normal and reduced tidal volumes. These effects were mediated primarily by a reduction in hindquarter vascular resistance. Lidocaine into a ventromedial site (8.0 mm beneath dura, 0.9 mm lateral to midline) increased MAP by increasing renal, mesenteric, and hindquarter vascular resistance. After sino-aortic deafferentation (SAD), reduced tidal volume augmented the pressor and blunted the tachycardic responses to lidocaine injected into the ventromedial pons (9.0 mm beneath dura, 0.9 mm lateral to midline). SAD also enhanced the pressor response to lidocaine injected into ventromedial pons. This work demonstrates a role for supra-medullary sites in the tonic control of vasomotor tone.

Tonic control of arterial pressure and regional hemodynamics by supra-medullary sites. Publishing Authors By Initials

BF Cox,MJ Brody,

For similar nervous system: peripheral nervous system: autonomic nervous system: sympathetic nervous system: vasomotor system research abstracts see: nervous system: peripheral nervous system: autonomic nervous system: sympathetic nervous system: vasomotor system research

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Tonic control of arterial pressure and regional hemodynamics by supra-medullary sites. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Clinical and experimental hypertension. Part A, Th

VOLUME: 13

Page Numbers: 197-218

Journal Abbreviation:

ISSN: 0730-0077

DAY: 12

MONTH: 02

YEAR: 1991

Tonic control of arterial pressure and regional hemodynamics by supra-medullary sites. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8207790

Tonic control of arterial pressure and regional hemodynamics by supra-medullary sites. Keywords Mesh Terms:

KEYWORDS: Vasomotor System

MESH TERMS: physiology

Chemical & Substance for Abstract: Tonic control of arterial pressure and regional hemodynamics by supra-medullary sites. Information

Substance Name: Lidocaine

Registry Number: 137-58-6

Grant and Affiliation Information for Tonic control of arterial pressure and regional hemodynamics by supra-medullary sites.

AFFILIATION: Department of Pharmacology, University of Iowa, Iowa City 52242.

Country: UNITED STATES

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MEDLINETA: Clin Exp Hypertens A

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