Toll-like receptor 2 plays a critical role in the progression of atherosclerosis that is independent of dietary lipids.

Toll-like receptor 2 plays a critical role in the progression of atherosclerosis that is independent of dietary lipids. Research Abstract Details 

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Toll-like receptor 2 plays a critical role in the progression of atherosclerosis that is independent of dietary lipids. Abstract Text:

Xinyan Liu,Takashi Ukai,Hiromichi Yumoto,Michael Davey,Sulip Goswami,Frank C Gibson,Caroline A Genco,Xinyan Liu,Takashi Ukai,Hiromichi Yumoto,Michael Davey,Sulip Goswami,Frank C Gibson,Caroline A Genco,

OBJECTIVE: Toll-like receptors (TLRs), a group of pathogen-associated microbial pattern recognition receptors, play an important role in innate immune signaling and are differentially regulated in chronic inflammatory diseases such as atherosclerosis. However, the involvement of TLRs in the progression of atherosclerosis is still unclear. METHODS AND RESULTS: TLR2 and apolipoprotein E double knockout (Tlr2(-/-)Apoe(-/-)) mice were generated and the progressive formation of atherosclerotic plaque in the aortas was examined in mice fed a normal chow diet. We demonstrate that inactivation of TLR2 resulted in reduced progression of atherosclerosis in both male and female Apoe(-/-) mice. Likewise, TLR2 deficiency resulted in a reduction in lipid accumulation and decreased macrophage recruitment to the aortic sinus, as well as reduced monocyte chemoattractant protein-1 (MCP-1) levels. Furthermore, macrophages isolated from Tlr2(-/-)Apoe(-/-) mice demonstrated significantly reduced MCP-1 production upon stimulation with a TLR2 ligand. However, no differences in acetylated low-density lipoprotein uptake and foam cell formation were observed in macrophages isolated from Tlr2(-/-)Apoe(-/-) mice as compared to Apoe(-/-) mice. CONCLUSIONS: TLR2 plays a critical role in the progression of atherosclerosis in Apoe(-/-) mice, which is independent of dietary lipids and macrophage lipid uptake.

Toll-like receptor 2 plays a critical role in the progression of atherosclerosis that is independent of dietary lipids. Publishing Authors By Initials

X Liu,T Ukai,H Yumoto,M Davey,S Goswami,FC Gibson,CA Genco,X Liu,T Ukai,H Yumoto,M Davey,S Goswami,FC Gibson,CA Genco,

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Toll-like receptor 2 plays a critical role in the progression of atherosclerosis that is independent of dietary lipids. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Atherosclerosis

VOLUME: 196

Page Numbers: 146-54

Journal Abbreviation: Atherosclerosis

ISSN: 1879-1484

DAY: 26

MONTH: 04

YEAR: 2007

Toll-like receptor 2 plays a critical role in the progression of atherosclerosis that is independent of dietary lipids. Information

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LANGUAGE: eng

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AFFILIATION: Department of Medicine, Section of Molecular Medicine, Boston University School of Medicine, 650 Albany Street, Boston, MA 02118, United States.

Country: Ireland

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MEDLINETA: Atherosclerosis

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