Toll-like receptor 2 contributes to glial cell activation and heme oxygenase-1 expression in traumatic brain injury.

Toll-like receptor 2 contributes to glial cell activation and heme oxygenase-1 expression in traumatic brain injury. Research Abstract Details 

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Toll-like receptor 2 contributes to glial cell activation and heme oxygenase-1 expression in traumatic brain injury. Abstract Text:

Chanhee Park,Ik-Hyun Cho,Donghoon Kim,Eun-Kyeong Jo,Se-Young Choi,Seog Bae Oh,Kyoungpyo Park,Joong Soo Kim,Sung Joong Lee,

Traumatic brain injury is accompanied by glial cell activation around the site of the injury. In this study, we investigated the role of toll-like receptor 2 (TLR2) in glial cell activation using a stab-wound injury (SWI) model with TLR2 knock-out mice. Penetration of a normal mouse brain with a 26-G needle using a stereotaxic instrument resulted in an 18- and 4-fold upregulation of GFAP and CD11b mRNA, respectively, along the needle track in the injury area. However, in the TLR2 knock-out mice, the induced expression of these genes was reduced by 70% and 40%, respectively. Likewise, there was a reduction in the area of activated glial cells detected by immunohistochemistry and the glial cells had a less-activated morphology in the TLR2 knock-out mice. In addition, the expression of the heme oxygenase-1 (HO-1) gene, a glia-expressing wound-responsive gene, was reduced after SWI in TLR2 knock-out mice. Taken together, these data argue that TLR2 contributes to the glial cell activation and HO-1 gene expression associated with traumatic brain injury.

Toll-like receptor 2 contributes to glial cell activation and heme oxygenase-1 expression in traumatic brain injury. Publishing Authors By Initials

C Park,IH Cho,D Kim,EK Jo,SY Choi,SB Oh,K Park,JS Kim,SJ Lee,

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Toll-like receptor 2 contributes to glial cell activation and heme oxygenase-1 expression in traumatic brain injury. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Neuroscience letters

VOLUME: 431

Page Numbers: 123-8

Journal Abbreviation: Neurosci. Lett.

ISSN: 0304-3940

DAY: 7

MONTH: 12

YEAR: 2007

Toll-like receptor 2 contributes to glial cell activation and heme oxygenase-1 expression in traumatic brain injury. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Toll-like receptor 2 contributes to glial cell activation and heme oxygenase-1 expression in traumatic brain injury.

AFFILIATION: Program in Molecular and Cellular Neuroscience, DRI, and Department of Oral Physiology, School of Dentistry, Seoul National University, 28 Yeongun-dong, Jongno-gu, Seoul 110-749, Republic of Korea.

Country: Ireland

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MEDLINETA: Neurosci Lett

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