Tolerogenic dendritic cells transferring hyporesponsiveness and synergizing T regulatory cells in transplant tolerance.

Tolerogenic dendritic cells transferring hyporesponsiveness and synergizing T regulatory cells in transplant tolerance. Research Abstract Details 

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Tolerogenic dendritic cells transferring hyporesponsiveness and synergizing T regulatory cells in transplant tolerance. Abstract Text:

Mu Li,Xusheng Zhang,Xiufen Zheng,Dameng Lian,Zhu-Xu Zhang,Hongtao Sun,Motohiko Suzuki,Costin Vladau,Xuyan Huang,Xiaoping Xia,Robert Zhong,Bertha Garcia,Wei-Ping Min,Mu Li,Xusheng Zhang,Xiufen Zheng,Dameng Lian,Zhu-Xu Zhang,Hongtao Sun,Motohiko Suzuki,Costin Vladau,Xuyan Huang,Xiaoping Xia,Robert Zhong,Bertha Garcia,Wei-Ping Min,

Dendritic cells are among the most potent antigen-presenting cells and are important in the development of both immunity and tolerance. Tolerogenic dendritic cell (Tol-DC) is a key factor in the induction and maintenance of tolerance during transplantation. However, the precise mechanism and direct evidence of in vivo immune modulation remain unclear. In the present study, we identified critical roles of immune modulation on transplant tolerance through interactions between Tol-DCs and regulatory T (Treg) cells. Tol-DCs remained in an immature state and were insensitive to maturation stimuli. Tol-DCs in tolerant recipients heightened the expression of indoleamine 2,3-dioxygenase (IDO) that induced allogeneic T-cell apoptosis. Adoptive transfer of Tol-DCs isolated from primary tolerant recipients resulted in augmentation of CD4(+)CD25(+)CTLA4(+) Treg cells and prolonged graft survival in secondary allogeneic heart transplantation and synergized with Treg cells to induce tolerance in secondary recipients. This study indicates that Tol-DC offers two functions during the process of tolerogenesis: suppression of anti-donor T-cell responses through production of IDO and interaction with Treg cells, which provides a framework for future research into tolerance induction.

Tolerogenic dendritic cells transferring hyporesponsiveness and synergizing T regulatory cells in transplant tolerance. Publishing Authors By Initials

M Li,X Zhang,X Zheng,D Lian,ZX Zhang,H Sun,M Suzuki,C Vladau,X Huang,X Xia,R Zhong,B Garcia,WP Min,M Li,X Zhang,X Zheng,D Lian,ZX Zhang,H Sun,M Suzuki,C Vladau,X Huang,X Xia,R Zhong,B Garcia,WP Min,

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Tolerogenic dendritic cells transferring hyporesponsiveness and synergizing T regulatory cells in transplant tolerance. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International immunology

VOLUME: 20

Page Numbers: 285-93

Journal Abbreviation: Int. Immunol.

ISSN: 0953-8178

DAY: 7

MONTH: 01

YEAR: 2008

Tolerogenic dendritic cells transferring hyporesponsiveness and synergizing T regulatory cells in transplant tolerance. Information

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LANGUAGE: eng

NlmUniqueID: 8916182

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Grant and Affiliation Information for Tolerogenic dendritic cells transferring hyporesponsiveness and synergizing T regulatory cells in transplant tolerance.

AFFILIATION: Department of Surgery, University of Western Ontario, London, Ontario, Canada.

Country: England

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MEDLINETA: Int Immunol

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