To be or not to be, the level of autophagy is the question: dual roles of autophagy in the survival response to starvation.

To be or not to be, the level of autophagy is the question: dual roles of autophagy in the survival response to starvation. Research Abstract Details 

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To be or not to be, the level of autophagy is the question: dual roles of autophagy in the survival response to starvation. Abstract Text:

Chanhee Kang,Leon Avery,Chanhee Kang,Leon Avery,

Autophagy is an evolutionally conserved lysosomal pathway used to degrade and turn over long-lived proteins and cytoplasmic organelles. Since autophagy was discovered, it has been thought to act as a pro-survival response to several stresses, especially starvation, at the cell and organism levels by providing recycled metabolic substrates to maintain energy homeostasis. However, several recent studies suggest that autophagy also plays a pro-death role through an autophagic cell death pathway mostly at the cellular level. The mechanism by which autophagy could perform these seemingly opposite roles as a pro-survival and a pro-death mechanism remained elusive until recently. Using C. elegans as a model system, we found that physiological levels of autophagy promote optimal survival of C. elegans during starvation, but either insufficient or excessive levels of autophagy render C. elegans starvation-hypersensitive. Furthermore, we found that muscarinic acetylcholine receptor signaling is important in modulating the level of autophagy during starvation, perhaps through DAP kinase and RGS-2. Our recent study provides in vivo evidence that levels of autophagy are critical in deciding its promotion of either survival or death: Physiological levels of autophagy are pro-survival, whereas insufficient or excessive levels of autophagy are pro-death.

To be or not to be, the level of autophagy is the question: dual roles of autophagy in the survival response to starvation. Publishing Authors By Initials

C Kang,L Avery,C Kang,L Avery,

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To be or not to be, the level of autophagy is the question: dual roles of autophagy in the survival response to starvation. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Autophagy

VOLUME: 4

Page Numbers: 82-4

Journal Abbreviation: Autophagy

ISSN: 1554-8635

DAY: 12

MONTH: 10

YEAR: 2007

To be or not to be, the level of autophagy is the question: dual roles of autophagy in the survival response to starvation. Information

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LANGUAGE: eng

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AFFILIATION: Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9148, USA. Chanhee.Kang@UTSouthwestern.edu

Country: United States

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MEDLINETA: Autophagy

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