TNF Microsatellite Alleles in Brazilian Chagasic Patients.

TNF Microsatellite Alleles in Brazilian Chagasic Patients. Research Abstract Details 

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TNF Microsatellite Alleles in Brazilian Chagasic Patients. Abstract Text:

Viriato Campelo,Roberto O Dantas,Renata T ,Celso T Mendes-Junior,Sandra M B Sousa,Aguinaldo L ,Eduardo A Donadi,Viriato Campelo,Roberto O Dantas,Renata T ,Celso T Mendes-Junior,Sandra M B Sousa,Aguinaldo L ,Eduardo A Donadi,Viriato Campelo,Roberto O Dantas,Renata T ,Celso T Mendes-Junior,Sandra M B Sousa,Aguinaldo L ,Eduardo A Donadi,

To evaluate the tumor necrosis factor (TNF) a-e microsatellite polymorphism in Chagasic patients, we studied 162 patients stratified according to the major clinical variants (cardiac, digestive, digestive plus cardiac, and indeterminate forms) and 221 healthy controls. TNF microsatellite alleles were typed using genomic DNA amplified with specific primers. Statistical analyses were performed using the GENEPOP and ARLEQUIN softwares and the two-tailed Fisher exact test. The TNFa2, TNFa7, TNFa8, TNFb2, TNFb4, TNFd5, TNFd7, and TNFe2 alleles were overrepresented, whereas the TNFb7 and TNFd3 alleles were underrepresented when clinical variants of Chagas' disease or the patient group as a whole were compared with controls. Twelve TNF haplotypes were associated with susceptibility to or protection against Chagas' disease, considered as a whole or stratified into clinical variants. Many of these haplotypes encompassed the above-described susceptibility/protective alleles. These results indicate that the TNF chromosomal region is relevant for Chagas' disease development.

TNF Microsatellite Alleles in Brazilian Chagasic Patients. Publishing Authors By Initials

V Campelo,RO Dantas,RT ,CT Mendes-Junior,SM Sousa,AL ,EA Donadi,V Campelo,RO Dantas,RT ,CT Mendes-Junior,SM Sousa,AL ,EA Donadi,V Campelo,RO Dantas,RT ,CT Mendes-Junior,SM Sousa,AL ,EA Donadi,

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TNF Microsatellite Alleles in Brazilian Chagasic Patients. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Digestive diseases and sciences

VOLUME: 52

Page Numbers: 3334-9

Journal Abbreviation: Dig. Dis. Sci.

ISSN: 0163-2116

DAY: 23

MONTH: 08

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 7902782

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AFFILIATION: Department of Parasitology and Microbiology, Center of Health Science (CCS), University Federal of Piauí (UFPI), Teresina-PI, Brazil.

Country: United States

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MEDLINETA: Dig Dis Sci

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