TNA synthesis by DNA polymerases.

TNA synthesis by DNA polymerases. Research Abstract Details 

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TNA synthesis by DNA polymerases. Abstract Text:

John C Chaput,Jack W Szostak,

Threose nucleic acid (TNA), which has a repeat unit one atom shorter than that of DNA, is capable of Watson-Crick base pairing with DNA, RNA, and TNA. Because of its chemical simplicity, TNA is considered to be a possible progenitor of RNA. As an initial step toward developing the molecular tools necessary to investigate the functional capabilities of TNA by in vitro selection, we have screened a variety of DNA polymerases for TNA synthesis activity on a DNA template. We wish to report that several polymerases show surprisingly good ability to synthesize TNA using alpha-l-threofuranosyl thymidine-3'-triphosphate as a substrate.

TNA synthesis by DNA polymerases. Publishing Authors By Initials

JC Chaput,JW Szostak,

For similar carbohydrates: monosaccharides: tetroses research abstracts see: carbohydrates: monosaccharides: tetroses research

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TNA synthesis by DNA polymerases. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of the American Chemical Society

VOLUME: 125

Page Numbers: 9274-5

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 6

MONTH: Aug

YEAR: 2003

TNA synthesis by DNA polymerases. Information

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LANGUAGE: eng

NlmUniqueID: 7503056

TNA synthesis by DNA polymerases. Keywords Mesh Terms:

KEYWORDS: Tetroses

MESH TERMS: chemistry

Chemical & Substance for Abstract: TNA synthesis by DNA polymerases. Information

Substance Name: DNA-Directed DNA Polymerase

Registry Number: EC 2.7.7.7

Grant and Affiliation Information for TNA synthesis by DNA polymerases.

AFFILIATION: Howard Hughes Medical Institute, and Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

Country: United States

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MEDLINETA: J Am Chem Soc

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